日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanism-based peroxiredoxin 3 inhibitors exploit a covalent warhead for cancer therapy

基于机制的过氧化物酶3抑制剂利用共价活性基团进行癌症治疗。

Nelson, Kimberly J; Smalley, Terrence L Jr; Messier, Terri; Gumpena, Rajesh; Gandhi, Uma; Milczarek, Stephanie; Habibovic, Aida; Hoffman, Hattie; Gibson, Victoria; Hondal, Robert J; Lowther, W Todd; Cunniff, Brian

Opportunities in Primary and Enteric Hyperoxaluria at the Cross-Roads Between the Clinic and Laboratory

原发性和肠源性高草酸尿症的机遇:临床与实验室的交汇点

Cellini, Barbara; Baum, Michelle A; Frishberg, Yaacov; Groothoff, Jaap W; Harris, Peter C; Hulton, Sally A; Knauf, Felix; Knight, John; Lieske, John C; Lowther, W Todd; Moochhala, Shabbir; Nazzal, Lama; Tasian, Gregory E; Whittamore, Jonathan M; Sas, David J

Cannabinoid receptor interacting protein 1a interacts with myristoylated Gα(i) N terminus via a unique gapped β-barrel structure.

大麻素受体相互作用蛋白 1a 通过独特的间隙 β-桶结构与肉豆蔻酰化的 Gα(i) N 末端相互作用

Booth William T, Clodfelter Jill E, Leone-Kabler Sandra, Hughes Erin K, Eldeeb Khalil, Howlett Allyn C, Lowther W Todd

End Points for Clinical Trials in Primary Hyperoxaluria

原发性高草酸尿症临床试验的终点

Milliner, Dawn S; McGregor, Tracy L; Thompson, Aliza; Dehmel, Bastian; Knight, John; Rosskamp, Ralf; Blank, Melanie; Yang, Sixun; Fargue, Sonia; Rumsby, Gill; Groothoff, Jaap; Allain, Meaghan; West, Melissa; Hollander, Kim; Lowther, W Todd; Lieske, John C

Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease

大麻素受体相互作用蛋白1a (CRIP1a) 在健康和疾病中的作用

Oliver, Emily E; Hughes, Erin K; Puckett, Meaghan K; Chen, Rong; Lowther, W Todd; Howlett, Allyn C

Peroxiredoxins in Cancer and Response to Radiation Therapies

过氧化物酶在癌症和放射治疗反应中的作用

Forshaw, Tom E; Holmila, Reetta; Nelson, Kimberly J; Lewis, Joshua E; Kemp, Melissa L; Tsang, Allen W; Poole, Leslie B; Lowther, W Todd; Furdui, Cristina M

Aromatic Residues at the Dimer-Dimer Interface in the Peroxiredoxin Tsa1 Facilitate Decamer Formation and Biological Function

过氧化物酶Tsa1二聚体-二聚体界面处的芳香族残基促进十聚体形成及其生物学功能

Loberg, Matthew A; Hurtig, Jennifer E; Graff, Aaron H; Allan, Kristin M; Buchan, John A; Spencer, Matthew K; Kelly, Joseph E; Clodfelter, Jill E; Morano, Kevin A; Lowther, W Todd; West, James D

Hydroxyproline Metabolism and Oxalate Synthesis in Primary Hyperoxaluria

原发性高草酸尿症中的羟脯氨酸代谢和草酸合成

Fargue, Sonia; Milliner, Dawn S; Knight, John; Olson, Julie B; Lowther, W Todd; Holmes, Ross P

Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines

开发一种对人类肿瘤细胞系具有增强细胞毒性的奥利司他自组装纳米颗粒制剂(Nano-ORL)

Hill, Tanner K; Davis, Amanda L; Wheeler, Frances B; Kelkar, Sneha S; Freund, Erica C; Lowther, W Todd; Kridel, Steven J; Mohs, Aaron M

Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria

脯氨酸脱氢酶 2 (PRODH2) 是一种羟脯氨酸脱氢酶 (HYPDH),也是治疗原发性高草酸尿症的分子靶点。

Summitt, Candice B; Johnson, Lynnette C; Jönsson, Thomas J; Parsonage, Derek; Holmes, Ross P; Lowther, W Todd