Recombinant SARS-Cov-2 spike protein S1 subunit upregulates P2âÃâ7-NLRP3 leading to macrophage pyroptosis promoting acute lung injury.
重组 SARS-Cov-2 刺突蛋白 S1 亚基上调 P2Â×Â7-NLRP3,导致巨噬细胞焦亡,从而促进急性肺损伤。
期刊:Respiratory Research
影响因子:5
doi:10.1186/s12931-026-03513-9
Lu Manlu, Li Mingzhen, Zhou Huijie, Zhu Jiwei, Jiao Qianqian, Liu Xiaojing, Wu Jinglin, Xu Guogang, Lv Changjun, Fan Yichu, Zhang Bin, Pan Lei
巨噬细胞
表观遗传
巨噬细胞
LRP3
焦亡
NLRP3
细胞生物学
免疫/内分泌