Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylation.
肠道代谢产物 TMAO 通过组蛋白 H4 赖氨酸 12 乳酸化刺激巨噬细胞 M2 极化，从而促进 CKD 进展。
期刊:Cell Death and Differentiation
影响因子:15.4
doi:10.1038/s41418-025-01554-z
Tang Youzhou, Li Yuxin, Yang Xinyu, Lu Tianze, Wang Xinran, Li Zhi, Liu Jun, Wang Jianwen
