PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model
PARK14 (D331Y) PLA2G6 在敲入小鼠模型中诱导线粒体功能障碍、内质网应激、线粒体自噬障碍和转录失调,导致黑质多巴胺能神经元早发性变性
期刊:Molecular Neurobiology
影响因子:4.6
doi:10.1007/s12035-018-1118-5
Ching-Chi Chiu, Chin-Song Lu, Yi-Hsin Weng, Ying-Ling Chen, Ying-Zu Huang, Rou-Shayn Chen, Yi-Chuan Cheng, Yin-Cheng Huang, Yu-Chuan Liu, Szu-Chia Lai, Kun-Jun Lin, Yan-Wei Lin, Yu-Jie Chen, Chao-Lang Chen, Tu-Hsueh Yeh, Hung-Li Wang
信号转导
神经
细胞生物学
Autophagy
Mouse