日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preclinical Development of SGN-CD47M: Protease-Activated Antibody Technology Enables Selective Tumor Targeting of the Innate Immune Checkpoint Receptor CD47.

SGN-CD47M 的临床前开发:蛋白酶激活抗体技术可选择性地靶向先天免疫检查点受体 CD47 的肿瘤

Levengood Matthew R, Carosino Christopher M, Zhang Xinqun, Lucas Sasha, Ortiz David J, Westendorf Lori, Chin Alice P, Martin Arlan D, Wong Abbie, Hengel Shawna M, Sun Hao, Zeng Weiping, Yumul Roma, Dominguez Melissa M C, Chen Yufei, Zheng Janet H, Karlsson Courtney A B, Trang Vivian H, Senter Peter D, Gardai Shyra J

Nonfucosylation of an anti-TIGIT antibody enhances FcγR engagement, driving innate immune activation and antitumor activity.

抗TIGIT抗体的非岩藻糖基化增强了FcγR的结合,从而驱动先天免疫激活和抗肿瘤活性

Smith Alyson J, Thurman Robert E, Zeng Weiping, Grogan Bryan, Lucas Sasha, Gutierrez Guadalupe, Heiser Ryan A, Wo Serena W, Blackmarr Amber, Peterson Scott, Gardai Shyra J