日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanding the toolbox to develop IAP-based degraders of TEAD transcription factors.

扩展工具箱,开发基于 IAP 的 TEAD 转录因子降解剂。

Gupta Nishma, Trainor Nicole, Radwan Mona, Nguyen Stephanie, Duncan Luke, Tang Andrew X, Beveridge Julia, Silke Natasha, Yousef Jumana, Bilgilier Ceren, Wachter Johannes, Greb Peter, Jandova Zuzana, Eliaš Ján, Kopf Sara, Gerstberger Thomas, Stolt-Bergner Peggy, Braun Nina, Weinstabl Harald, McConnell Darryl B, Mauri Federico, Lucet Isabelle S, Silke John, Chessum Nicola E A, Roy Michael J

ProteinDJ: A high-performance and modular protein design pipeline

ProteinDJ:高性能模块化蛋白质设计流程

Silke, Dylan; Iskander, Julie; Pan, Junqi; Thompson, Andrew P; Papenfuss, Anthony T; Lucet, Isabelle S; Hardy, Joshua M

Illuminating the druggability of the Giardia duodenalis kinome through reannotation and high-throughput screens

通过重新注释和高通量筛选揭示十二指肠贾第鞭毛虫激酶组的可成药性

Lam, Alexander Y F; Lucet, Isabelle S; Jex, Aaron R; Emery-Corbin, Samantha J

Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis

基于结构的DCLK1突变对肿瘤发生功能影响的预测

Carli, Annalisa L E; Hardy, Joshua M; Hoblos, Hanadi; Ernst, Matthias; Lucet, Isabelle S; Buchert, Michael

Crystal structure of the putative cell-wall lipoglycan biosynthesis protein LmcA from Mycobacterium smegmatis

耻垢分枝杆菌假定的细胞壁脂聚糖生物合成蛋白LmcA的晶体结构

Patel, Onisha; Brammananth, Rajini; Dai, Weiwen; Panjikar, Santosh; Coppel, Ross L; Lucet, Isabelle S; Crellin, Paul K

Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix

颗粒病毒PK-1激酶活性依赖于以调控αC螺旋为中心的侧向二聚化模式。

Oliver, Michael R; Horne, Christopher R; Shrestha, Safal; Keown, Jeremy R; Liang, Lung-Yu; Young, Samuel N; Sandow, Jarrod J; Webb, Andrew I; Goldstone, David C; Lucet, Isabelle S; Kannan, Natarajan; Metcalf, Peter; Murphy, James M

Flicking the molecular switch underlying MLKL-mediated necroptosis

拨动MLKL介导的坏死性凋亡的分子开关

Hildebrand, Joanne M; Lucet, Isabelle S; Murphy, James M

The molecular regulation of Janus kinase (JAK) activation

Janus激酶(JAK)激活的分子调控

Babon, Jeffrey J; Lucet, Isabelle S; Murphy, James M; Nicola, Nicos A; Varghese, Leila N

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

通过生化和结构分析,深入了解骨髓增生性肿瘤相关JAK2突变体的激活和SOCS3介导的抑制机制

Varghese, Leila N; Ungureanu, Daniela; Liau, Nicholas P D; Young, Samuel N; Laktyushin, Artem; Hammaren, Henrik; Lucet, Isabelle S; Nicola, Nicos A; Silvennoinen, Olli; Babon, Jeffrey J; Murphy, James M

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

一种基于核苷酸结合特性对假激酶进行亚分类的可靠方法

Murphy, James M; Zhang, Qingwei; Young, Samuel N; Reese, Michael L; Bailey, Fiona P; Eyers, Patrick A; Ungureanu, Daniela; Hammaren, Henrik; Silvennoinen, Olli; Varghese, Leila N; Chen, Kelan; Tripaydonis, Anne; Jura, Natalia; Fukuda, Koichi; Qin, Jun; Nimchuk, Zachary; Mudgett, Mary Beth; Elowe, Sabine; Gee, Christine L; Liu, Ling; Daly, Roger J; Manning, Gerard; Babon, Jeffrey J; Lucet, Isabelle S