日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Regulatory grammar in human promoters uncovered by MPRA-based deep learning

基于MPRA的深度学习揭示了人类启动子中的调控语法

Barbadilla-Martínez, Lucía; Klaassen, Noud; Franceschini-Santos, Vinícius H; Breda, Jérémie; Yücel, Hatice; Hernández-Quiles, Miguel; van Lieshout, Tijs; Urzua Traslaviña, Carlos G; Boi, Minh Chau Luong; Akbarzadeh, Maryam; Hermana-Garcia-Agullo, Celia; Gregoricchio, Sebastian; de Haas, Marcel; Straver, Roy; Derks, Sarah; Zwart, Wilbert; Voest, Emile; Franke, Lude; Vermeulen, Michiel; de Ridder, Jeroen; van Steensel, Bas

Charles Weissmann (1931–2025), an outstanding and captivating molecular biologist

查尔斯·魏斯曼(1931–2025),一位杰出而富有魅力的分子生物学家

van Rheenen, Wouter; van der Spek, Rick A A; Bakker, Mark K; van Vugt, Joke J F A; Hop, Paul J; Zwamborn, Ramona A J; de Klein, Niek; Westra, Harm-Jan; Bakker, Olivier B; Deelen, Patrick; Shireby, Gemma; Hannon, Eilis; Moisse, Matthieu; Baird, Denis; Restuadi, Restuadi; Dolzhenko, Egor; Dekker, Annelot M; Gawor, Klara; Westeneng, Henk-Jan; Tazelaar, Gijs H P; van Eijk, Kristel R; Kooyman, Maarten; Byrne, Ross P; Doherty, Mark; Heverin, Mark; Al Khleifat, Ahmad; Iacoangeli, Alfredo; Shatunov, Aleksey; Ticozzi, Nicola; Cooper-Knock, Johnathan; Smith, Bradley N; Gromicho, Marta; Chandran, Siddharthan; Pal, Suvankar; Morrison, Karen E; Shaw, Pamela J; Hardy, John; Orrell, Richard W; Sendtner, Michael; Meyer, Thomas; Başak, Nazli; van der Kooi, Anneke J; Ratti, Antonia; Fogh, Isabella; Gellera, Cinzia; Lauria, Giuseppe; Corti, Stefania; Cereda, Cristina; Sproviero, Daisy; D'Alfonso, Sandra; Sorarù, Gianni; Siciliano, Gabriele; Filosto, Massimiliano; Padovani, Alessandro; Chiò, Adriano; Calvo, Andrea; Moglia, Cristina; Brunetti, Maura; Canosa, Antonio; Grassano, Maurizio; Beghi, Ettore; Pupillo, Elisabetta; Logroscino, Giancarlo; Nefussy, Beatrice; Osmanovic, Alma; Nordin, Angelica; Lerner, Yossef; Zabari, Michal; Gotkine, Marc; Baloh, Robert H; Bell, Shaughn; Vourc'h, Patrick; Corcia, Philippe; Couratier, Philippe; Millecamps, Stéphanie; Meininger, Vincent; Salachas, François; Mora Pardina, Jesus S; Assialioui, Abdelilah; Rojas-García, Ricardo; Dion, Patrick A; Ross, Jay P; Ludolph, Albert C; Weishaupt, Jochen H; Brenner, David; Freischmidt, Axel; Bensimon, Gilbert; Brice, Alexis; Durr, Alexandra; Payan, Christine A M; Saker-Delye, Safa; Wood, Nicholas W; Topp, Simon; Rademakers, Rosa; Tittmann, Lukas; Lieb, Wolfgang; Franke, Andre; Ripke, Stephan; Braun, Alice; Kraft, Julia; Whiteman, David C; Olsen, Catherine M; Uitterlinden, Andre G; Hofman, Albert; Rietschel, Marcella; Cichon, Sven; Nöthen, Markus M; Amouyel, Philippe; Traynor, Bryan J; Singleton, Andrew B; Mitne Neto, Miguel; Cauchi, Ruben J; Ophoff, Roel A; Wiedau-Pazos, Martina; Lomen-Hoerth, Catherine; van Deerlin, Vivianna M; Grosskreutz, Julian; Roediger, Annekathrin; Gaur, Nayana; Jörk, Alexander; Barthel, Tabea; Theele, Erik; Ilse, Benjamin; Stubendorff, Beatrice; Witte, Otto W; Steinbach, Robert; Hübner, Christian A; Graff, Caroline; Brylev, Lev; Fominykh, Vera; Demeshonok, Vera; Ataulina, Anastasia; Rogelj, Boris; Koritnik, Blaž; Zidar, Janez; Ravnik-Glavač, Metka; Glavač, Damjan; Stević, Zorica; Drory, Vivian; Povedano, Monica; Blair, Ian P; Kiernan, Matthew C; Benyamin, Beben; Henderson, Robert D; Furlong, Sarah; Mathers, Susan; McCombe, Pamela A; Needham, Merrilee; Ngo, Shyuan T; Nicholson, Garth A; Pamphlett, Roger; Rowe, Dominic B; Steyn, Frederik J; Williams, Kelly L; Mather, Karen A; Sachdev, Perminder S; Henders, Anjali K; Wallace, Leanne; de Carvalho, Mamede; Pinto, Susana; Petri, Susanne; Weber, Markus; Rouleau, Guy A; Silani, Vincenzo; Curtis, Charles J; Breen, Gerome; Glass, Jonathan D; Brown, Robert H Jr; Landers, John E; Shaw, Christopher E; Andersen, Peter M; Groen, Ewout J N; van Es, Michael A; Pasterkamp, R Jeroen; Fan, Dongsheng; Garton, Fleur C; McRae, Allan F; Davey Smith, George; Gaunt, Tom R; Eberle, Michael A; Mill, Jonathan; McLaughlin, Russell L; Hardiman, Orla; Kenna, Kevin P; Wray, Naomi R; Tsai, Ellen; Runz, Heiko; Franke, Lude; Al-Chalabi, Ammar; Van Damme, Philip; van den Berg, Leonard H; Veldink, Jan H; Borst, Piet; Flavell, Richard A

SMARCA4 deficiency in glioblastoma: Mitochondrial transfer from MSCs and the clinical dilemma in targeting the tumor microenvironment

胶质母细胞瘤中SMARCA4缺陷:来自间充质干细胞的线粒体转移以及靶向肿瘤微环境的临床困境

Yang, Fan; Chen, Lin; Shi, Yuchen; Wang, Lude; Tong, Minfeng

Accelerating rare disease diagnostics by linking DNA and RNA through an explainable and interactive RNA-guided workflow

通过可解释且交互式的RNA引导工作流程,将DNA和RNA联系起来,从而加速罕见病诊断。

Maassen, Willem T K; Pape, Charlotte C E T; Urzua-Traslavina, Carlos G; Niemeijer, Tim; van Lieshout, Tijs; van der Molen, Margriet; Johansson, Lennart F; van der Velde, Kasper J; Franke, Lude; van Gijn, Mariëlle E; Swertz, Morris A

Federated single-cell QTL meta-analysis reveals novel disease mechanisms

联合单细胞QTL荟萃分析揭示了新的疾病机制

Kaptijn, Daniel; Michielsen, Lieke; Neavin, Drew; Ripoll-Cladellas, Aida; Alquicira-Hernández, José; Korshevniuk, Maryna; Lee, Jimmy Tsz Hang; Oelen, Roy; Vochteloo, Martijn; Warmerdam, Robert; Ando, Yoshinari; Ban, Maria; Bayaraa, Odmaa; Berg, Marijn; van Blokland, Irene; Considine, Daniel; Dieng, Mame M; Edahiro, Ryuya; Gordon, M Grace; Groot, Hilde E; van der Harst, Pim; Heinig, Matthias; Hon, Chung-Chau; Idaghdour, Youssef; Kathail, Pooja; de Klein, Niek; Li, Wenchao; Li, Yang; Losert, Corinna; Manikanda, Vinu; Moody, Jonathan; Naeem, Haroon; Mokrab, Younes; Nawijn, Martijn C; Netea, Mihai; Niewold, Jelmer; Okada, Yukinori; Sawcer, Stephen; Soulama, Issiaka; Stegle, Oliver; Tsepilov, Yakov; Park, Woong-Yang; Rajagopalan, Deepa; Shahin, Tala; Shin, Jay W; Trynka, Gosia; Võsa, Urmo; Westra, Harm-Jan; Yazar, Seyhan; Ye, Jimmie; Zhang, Zhenhua; Hemberg, Martin; Mahfouz, Ahmed; Melé, Marta; Powell, Joseph E; Bonder, Marc Jan; Franke, Lude; van der Wijst, Monique G P

DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease

参与脂质代谢的基因的DNA甲基化驱动脂联素水平和代谢性疾病

Sinke, Lucy; Delerue, Thomas; Wilson, Rory; Lu, Xueling; Xia, Yujing; Costeira, Ricardo; Nasr, M Kamal; Beekman, Marian; Franke, Lude; Zhernakova, Alexandra; Fu, Jingyuan; Gieger, Christian; Herder, Christian; Koenig, Wolfgang; Peters, Annette; Ordovas, José M; Dörr, Marcus; Grabe, Hans J; Nauck, Matthias; Bell, Jordana T; Teumer, Alexander; Snieder, Harold; Waldenberger, Melanie; Slagboom, P Eline; Heijmans, Bastiaan T

Genome-wide association study of long COVID

针对新冠长期症状的全基因组关联研究

Lammi, Vilma; Nakanishi, Tomoko; Jones, Samuel E; Andrews, Shea J; Karjalainen, Juha; Cortés, Beatriz; O'Brien, Heath E; Ochoa-Guzman, Ana; Fulton-Howard, Brian E; Broberg, Martin; Haapaniemi, Hele H; Kanai, Masahiro; Pirinen, Matti; Schmidt, Axel; Mitchell, Ruth E; Mousas, Abdou; Mangino, Massimo; Huerta-Chagoya, Alicia; Sinnott-Armstrong, Nasa; Cirulli, Elizabeth T; Vaudel, Marc; Kwong, Alex S F; Maiti, Amit K; Marttila, Minttu M; Posner, Daniel C; Rodriguez, Alexis A; Batini, Chiara; Minnai, Francesca; Dearman, Anna R; Warmerdam, C A Robert; Sequeros, Celia B; Winkler, Thomas W; Jordan, Daniel M; Rešcenko, Raimonds; Miano, Lorenzo; Lane, Jacqueline M; Chung, Ryan K; Guillen-Guio, Beatriz; Leavy, Olivia C; Carvajal-Silva, Laura; Aguilar-Valdés, Kevin; Frangione, Erika; Guare, Lindsay; Vergasova, Ekaterina; Marouli, Eirini; Striano, Pasquale; Zainulabid, Ummu Afeera; Kumar, Ashutosh; Ahmad, Hajar Fauzan; Edahiro, Ryuya; Azekawa, Shuhei; Luoh, Shiuh-Wen; Erikstrup, Christian; Pedersen, Ole B V; Lerner-Ellis, Jordan; Colombo, Alicia; Grzymski, Joseph J; Ishii, Makoto; Okada, Yukinori; Beckmann, Noam D; Kumari, Meena; Wagner, Ralf; Heid, Iris M; John, Catherine; Short, Patrick J; Magnus, Per; Ansone, Laura; Valenti, Luca V C; Lee, Sulggi A; Wain, Louise V; Verdugo, Ricardo A; Banasik, Karina; Geller, Frank; Franke, Lude H; Rakitko, Alexander; Duncan, Emma L; Renieri, Alessandra; Tsilidis, Konstantinos K; de Cid, Rafael; Niavarani, Ahmadreza; Abner, Erik; Tusié-Luna, Teresa; Verma, Shefali S; Smith, George Davey; Timpson, Nicholas J; Madduri, Ravi K; Cho, Kelly; Daly, Mark J; Ganna, Andrea; Schulte, Eva C; Richards, J Brent; Ludwig, Kerstin U; Marks-Hultström, Michael; Zeberg, Hugo; Ollila, Hanna M

MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality

MR-link-2:多效性稳健的顺式孟德尔随机化在三个独立的因果关系参考数据集中得到验证

van der Graaf, Adriaan; Warmerdam, Robert; Auwerx, Chiara; Võsa, Urmo; Borges, Maria Carolina; Franke, Lude; Kutalik, Zoltán

Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

跨eQTL定位将USP18确定为狼疮风险位点上干扰素反应的负调控因子

Freimann, Krista; Brümmer, Anneke; Warmerdam, Robert; Rupall, Tarran S; Hernández-Ledesma, Ana Laura; Chiou, Joshua; Holzinger, Emily R; Maranville, Joseph C; Nakic, Nikolina; Ongen, Halit; Stefanucci, Luca; Turchin, Michael C; Franke, Lude; Võsa, Urmo; Jones, Carla P; Medina-Rivera, Alejandra; Trynka, Gosia; Kisand, Kai; Bergmann, Sven; Alasoo, Kaur

LBX2 promotes colorectal cancer progression via the glycosylation and lactylation positive feedback

LBX2通过糖基化和乳酸化的正反馈促进结直肠癌的进展。

Jiang, Yiwen; Wang, Lude; Chen, Lin; Shen, Kai; Chang, Jie; Zheng, Shicong; Chen, Zewei; Ge, Chenyang; Yu, Min; Yu, Shian; Lin, Haiping