日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease

线粒体钙外流受损导致阿尔茨海默病模型中的病情进展

Pooja Jadiya, Devin W Kolmetzky, Dhanendra Tomar, Antonio Di Meco, Alyssa A Lombardi, Jonathan P Lambert, Timothy S Luongo, Marthe H Ludtmann, Domenico Praticò, John W Elrod

FBS/BSA media concentration determines CCCP's ability to depolarize mitochondria and activate PINK1-PRKN mitophagy

FBS/BSA 培养基浓度决定 CCCP 使线粒体去极化并激活 PINK1-PRKN 线粒体自噬的能力

Marc P M Soutar, Liam Kempthorne, Emily Annuario, Christin Luft, Selina Wray, Robin Ketteler, Marthe H R Ludtmann, Hélène Plun-Favreau

LRRK2 deficiency induced mitochondrial Ca(2+) efflux inhibition can be rescued by Na(+)/Ca(2+)/Li(+) exchanger upregulation

LRRK2 缺陷引起的线粒体 Ca(2+) 外流抑制可通过 Na(+)/Ca(2+)/Li(+) 交换器上调来挽救。

Ludtmann, Marthe H R; Kostic, Marko; Horne, Amy; Gandhi, Sonia; Sekler, Israel; Abramov, Andrey Y

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease

α-突触核蛋白寡聚体与 ATP 合酶相互作用并打开帕金森病中的通透性转换孔

Marthe H R Ludtmann, Plamena R Angelova, Mathew H Horrocks, Minee L Choi, Margarida Rodrigues, Artyom Y Baev, Alexey V Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T Ranasinghe, Daniel R Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J Devine, Paul Gissen, T

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy

核黄素反应性神经病变的临床、病理和功能特征

Manole, Andreea; Jaunmuktane, Zane; Hargreaves, Iain; Ludtmann, Marthe H R; Salpietro, Vincenzo; Bello, Oscar D; Pope, Simon; Pandraud, Amelie; Horga, Alejandro; Scalco, Renata S; Li, Abi; Ashokkumar, Balasubramaniem; Lourenço, Charles M; Heales, Simon; Horvath, Rita; Chinnery, Patrick F; Toro, Camilo; Singleton, Andrew B; Jacques, Thomas S; Abramov, Andrey Y; Muntoni, Francesco; Hanna, Michael G; Reilly, Mary M; Revesz, Tamas; Kullmann, Dimitri M; Jepson, James E C; Houlden, Henry

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

针对单体 ɑ-突触核蛋白的纳米抗体可抑制原纤维形成并破坏有毒寡聚物种类

Marija Iljina, Liu Hong, Mathew H Horrocks, Marthe H Ludtmann, Minee L Choi, Craig D Hughes, Francesco S Ruggeri, Tim Guilliams, Alexander K Buell, Ji-Eun Lee, Sonia Gandhi, Steven F Lee, Clare E Bryant, Michele Vendruscolo, Tuomas P J Knowles, Christopher M Dobson, Erwin De Genst, David Klenerman

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons

含缬氨酸蛋白(VCP)的突变会降低ADP/ATP跨线粒体膜的转运,并损害人类神经元的能量代谢。

Ludtmann, Marthe H R; Arber, Charles; Bartolome, Fernando; de Vicente, Macarena; Preza, Elisavet; Carro, Eva; Houlden, Henry; Gandhi, Sonia; Wray, Selina; Abramov, Andrey Y

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

突触核蛋白低聚物与金属离子相互作用,引发帕金森病中的氧化应激和神经元死亡

Emma Deas, Nunilo Cremades, Plamena R Angelova, Marthe H R Ludtmann, Zhi Yao, Serene Chen, Mathew H Horrocks, Blerida Banushi, Daniel Little, Michael J Devine, Paul Gissen, David Klenerman, Christopher M Dobson, Nicholas W Wood, Sonia Gandhi, Andrey Y Abramov

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase

单体 α-突触核蛋白对脑 ATP 合酶发挥生理作用

Marthe H R Ludtmann, Plamena R Angelova, Natalia N Ninkina, Sonia Gandhi, Vladimir L Buchman, Andrey Y Abramov

Ca2+ is a key factor in α-synuclein-induced neurotoxicity

Ca2+是α-突触核蛋白诱导神经毒性的关键因素

Angelova, Plamena R; Ludtmann, Marthe H R; Horrocks, Mathew H; Negoda, Alexander; Cremades, Nunilo; Klenerman, David; Dobson, Christopher M; Wood, Nicholas W; Pavlov, Evgeny V; Gandhi, Sonia; Abramov, Andrey Y