日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Clinically advanced NLRP3 inhibitor modulates microglial transcriptome and alleviates α-synuclein-induced progression of parkinsonism

临床上先进的NLRP3抑制剂可调节小胶质细胞转录组,并减轻α-突触核蛋白诱导的帕金森病进展。

Luque, Maria; Matic, Magdalena; Heras-Garvin, Antonio; Amo-Aparicio, Jesus; Luk, Kelvin C; Haindl, Michaela Tanja; Khalil, Michael; Skouras, Damaris B; Dinarello, Charles A; Stefanova, Nadia

Testing an inverse link between limbic alpha-synucleinopathy and myelin markers in mice and humans

在小鼠和人类中检验边缘系统α-突触核蛋白病与髓鞘标志物之间的反向关系

Clark, Rachel N; Landes, Reese E; Abbas, Muslim; Mistretta, Victoria G; Jhaveri, Jhanvi R; DeLoatch, Kieran A; Franks, Jonathan; Chen, Jun; Luk, Kelvin C; Hu, Xiaoming; Leak, Rehana K

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

快速诱导多能干细胞包涵体病模型揭示了α-突触核蛋白包涵体的形成、后果和分子亚型

Lam, Isabel; Ndayisaba, Alain; Lewis, Amanda J; Fu, YuHong; Sagredo, Giselle T; Kuzkina, Anastasia; Zaccagnini, Ludovica; Celikag, Meral; Sandoe, Jackson; Sanz, Ricardo L; Vahdatshoar, Aazam; Martin, Timothy D; Morshed, Nader; Ichihashi, Toru; Tripathi, Arati; Ramalingam, Nagendran; Oettgen-Suazo, Charlotte; Bartels, Theresa; Boussouf, Manel; Schäbinger, Max; Hallacli, Erinc; Jiang, Xin; Verma, Amrita; Tea, Challana; Wang, Zichen; Hakozaki, Hiroyuki; Yu, Xiao; Hyles, Kelly; Park, Chansaem; Wang, Xinyuan; Theunissen, Thorold W; Wang, Haoyi; Jaenisch, Rudolf; Lindquist, Susan; Stevens, Beth; Stefanova, Nadia; Wenning, Gregor; van de Berg, Wilma D J; Luk, Kelvin C; Sanchez-Pernaute, Rosario; Gómez-Esteban, Juan Carlos; Felsky, Daniel; Kiyota, Yasujiro; Sahni, Nidhi; Yi, S Stephen; Chung, Chee Yeun; Stahlberg, Henning; Ferrer, Isidro; Schöneberg, Johannes; Elledge, Stephen J; Dettmer, Ulf; Halliday, Glenda M; Bartels, Tim; Khurana, Vikram

Synphilin-1 modulates alpha-synuclein assembly, release and uptake.

Synphilin-1 调节 α-突触核蛋白的组装、释放和摄取。

Lázaro Diana F, Amen Triana, Gerhardt Ellen, Song Chengyuan, Burns Ryan, Kruse Niels, Santos Patrícia I, Milovanovic Dragomir, Höglinger Günter, Mollenhauer Brit, Luk Kelvin C, Lee Virginia My-, Outeiro Tiago F

Intrastriatal injection of alpha-synuclein preformed fibrils to rats results in L-DOPA reversible sensorimotor impairments and alterations in non-motor function.

向大鼠纹状体内注射α-突触核蛋白预成型原纤维会导致左旋多巴可逆的感觉运动障碍和非运动功能改变

Fleming Sheila M, Scott Sophia, Hamad Edward J, Herman Danielle E, Holden John G, Yan Lily, Linning-Duffy Katrina, Kemp Christopher J, Patterson Joseph R, Miller Kathryn M, Kubik Michael, Kuhn Nathan, Stoll Anna C, Duffy Megan F, Steece-Collier Kathy, Cole-Strauss Allyson, Lipton Jack W, Luk Kelvin C, Sortwell Caryl E

Author Correction: O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology

作者更正:O-GlcNAc 可诱导 α-突触核蛋白淀粉样变性,显著降低其种子形成和病理特征。

Balana, Aaron T; Mahul-Mellier, Anne-Laure; Nguyen, Binh A; Horvath, Mian; Javed, Afraah; Hard, Eldon R; Jasiqi, Yllza; Singh, Preeti; Afrin, Shumaila; Pedretti, Rose; Singh, Virender; Lee, Virginia M-Y; Luk, Kelvin C; Saelices, Lorena; Lashuel, Hilal A; Pratt, Matthew R

Current insights and assumptions on α-synuclein in Lewy body disease

目前对路易体病中α-突触核蛋白的认识和假设

Leak, Rehana K; Clark, Rachel N; Abbas, Muslim; Xu, Fei; Brodsky, Jeffrey L; Chen, Jun; Hu, Xiaoming; Luk, Kelvin C

Are Preformed Fibrils a Model of Parkinson's Disease?

预成纤维是帕金森病的模型吗?

Woerman, Amanda L; Luk, Kelvin C

The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex

人类、大鼠和小鼠体内磷酸化不溶性α-突触核蛋白的差异并非主要由生物性别驱动。

Miner, Kristin M; Jamenis, Anuj S; Bhatia, Tarun N; Clark, Rachel N; Abbas, Muslim; Luk, Kelvin C; Leak, Rehana K

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

O-GlcNAc修饰可促使α-突触核蛋白淀粉样蛋白菌株的形成,该菌株的种子活性和病理作用显著降低。

Balana, Aaron T; Mahul-Mellier, Anne-Laure; Nguyen, Binh A; Horvath, Mian; Javed, Afraah; Hard, Eldon R; Jasiqi, Yllza; Singh, Preeti; Afrin, Shumaila; Pedretti, Rose; Singh, Virender; Lee, Virginia M-Y; Luk, Kelvin C; Saelices, Lorena; Lashuel, Hilal A; Pratt, Matthew R