日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer

基因组规模的 CRISPR 筛选发现 PTGES3 是晚期前列腺癌中雄激素受体功能的直接调节因子

Haolong Li,James E Melnyk,Becky Xu Hua Fu,Raunak Shrestha,Meng Zhang,Martin Sjöström,Siyu Feng,Jasmine A Anderson,Wanting Han,Lisa N Chesner,Hyun Jin Shin,Tatyanah Farsh,Humberto J Suarez,Seema Nath,Jonathan Chou,Rajdeep Das,Emily A Egusa,Marsha Calvert,Audrey Kishishita,Abhilash Barpanda,Jun Zhu,Ashutosh Maheshwari,William S Chen,Mohammed Alshalalfa,Aidan Winters,Junjie T Hua,Tianyi Liu,Elai Davicioni,Arun P Wiita,Bradley A Stohr,Javed Siddiqui,Bo Huang,Eric J Small,Kevan M Shokat,Peter S Nelson,David A Quigley,Elizabeth V Wasmuth,Luke A Gilbert,Felix Y Feng

Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer

雄激素受体抑制可增加MHC I类分子的表达并改善前列腺癌的免疫反应

Lisa N Chesner ,Fanny Polesso ,Julie N Graff ,Jessica E Hawley ,Alexis K Smith ,Arian Lundberg ,Rajdeep Das ,Tanushree Shenoy ,Martin Sjöström ,Faming Zhao ,Ya-Mei Hu ,Simon Linder ,William S Chen ,Reed M Hawkins ,Raunak Shrestha ,Xiaolin Zhu ,Adam Foye ,Haolong Li ,Lisa M Kim ,Megha Bhalla ,Thomas O'loughlin ,Duygu Kuzuoglu-Ozturk ,Junjie T Hua ,Michelle L Badura ,Scott Wilkinson ,Shana Y Trostel ,Andries M Bergman ,Davide Ruggero ,Charles G Drake ,Adam G Sowalsky ,Lawrence Fong ,Matthew R Cooperberg ,Wilbert Zwart ,Xiangnan Guan ,Alan Ashworth ,Zheng Xia ,David A Quigley ,Luke A Gilbert ,Felix Y Feng # ,Amy E Moran #

FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry

FOXP3的表达依赖于细胞类型特异性的顺式调控元件和转录因子回路。

Jennifer M Umhoefer ,Maya M Arce ,Sivakanthan Kasinathan ,Sean Whalen ,Rama Dajani ,Sanjana Subramanya ,Laine Goudy ,Julia A Belk ,Royce Zhou ,Minh T N Pham ,Wenxi Zhang ,Rosmely Hernandez ,Carinna Tran ,Nikhita Kirthivasan ,Jacob W Freimer ,Cody T Mowery ,Vinh Nguyen ,Mineto Ota ,Benjamin G Gowen ,Dimitre R Simeonov ,Gemma L Curie ,Zhongmei Li ,Andy Y Chen ,Jacob E Corn ,Howard Y Chang ,Qizhi Tang ,Luke A Gilbert ,Ansuman T Satpathy ,Katherine S Pollard ,Alexander Marson

Improving prime editing with an endogenous small RNA-binding protein

利用内源性小RNA结合蛋白改善先导编辑

Jun Yan ,Paul Oyler-Castrillo ,Purnima Ravisankar ,Carl C Ward ,Sébastien Levesque ,Yangwode Jing ,Danny Simpson ,Anqi Zhao ,Hui Li ,Weihao Yan ,Laine Goudy ,Ralf Schmidt ,Sabrina C Solley ,Luke A Gilbert ,Michelle M Chan ,Daniel E Bauer ,Alexander Marson ,Lance R Parsons ,Britt Adamson

Base-editing mutagenesis maps alleles to tune human T cell functions

碱基编辑诱变技术通过绘制等位基因图谱来调节人类T细胞功能

Ralf Schmidt #,Carl C Ward #,Rama Dajani,Zev Armour-Garb,Mineto Ota,Vincent Allain,Rosmely Hernandez,Madeline Layeghi,Galen Xing,Laine Goudy,Dmytro Dorovskyi,Charlotte Wang,Yan Yi Chen,Chun Jimmie Ye,Brian R Shy,Luke A Gilbert,Justin Eyquem,Jonathan K Pritchard,Stacie E Dodgson,Alexander Marson

A systematic search for RNA structural switches across the human transcriptome

对人类转录组中RNA结构转换的系统性搜索

Matvei Khoroshkin,Daniel Asarnow,Shaopu Zhou,Albertas Navickas,Aidan Winters,Jackson Goudreau,Simon K Zhou,Johnny Yu,Christina Palka,Lisa Fish,Ashir Borah,Kian Yousefi,Christopher Carpenter,K Mark Ansel,Yifan Cheng,Luke A Gilbert,Hani Goodarzi

In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma

癌症和微环境细胞的体内扰动测序剖析了胶质母细胞瘤的肿瘤驱动因素和放射治疗反应

S John Liu, Christopher Zou, Joanna Pak, Alexandra Morse, Dillon Pang, Timothy Casey-Clyde, Ashir A Borah, David Wu, Kyounghee Seo, Thomas O'Loughlin, Daniel A Lim, Tomoko Ozawa, Mitchel S Berger, Roarke A Kamber, William A Weiss, David R Raleigh #, Luke A Gilbert #

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer

ENPP1 是乳腺癌抗癌 cGAMP-STING 通路的先天免疫检查点

Songnan Wang, Volker Böhnert, Alby J Joseph, Valentino Sudaryo, Gemini Skariah, Jason T Swinderman, Feiqiao B Yu, Vishvak Subramanyam, Denise M Wolf, Xuchao Lyu, Luke A Gilbert, Laura J Van't Veer, Hani Goodarzi, Lingyin Li

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

ENPP1 是抗癌 cGAMP-STING 通路的先天免疫检查点

Songnan Wang, Volker Böhnert, Alby J Joseph, Valentino Sudaryo, Jason Swinderman, Feiqiao B Yu, Xuchao Lyu, Gemini Skariah, Vishvak Subramanyam, Luke A Gilbert, Hani Goodarzi, Li Lingyin

Highly efficient generation of isogenic pluripotent stem cell models using prime editing

利用先导编辑技术高效构建同源多能干细胞模型

Hanqin Li #,Oriol Busquets #,Yogendra Verma,Khaja Mohieddin Syed,Nitzan Kutnowski,Gabriella R Pangilinan,Luke A Gilbert,Helen S Bateup,Donald C Rio,Dirk Hockemeyer,Frank Soldner