日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TERT activation targets DNA methylation and multiple aging hallmarks

TERT激活靶向DNA甲基化和多种衰老标志

Hong Seok Shim ,Jonathan Iaconelli ,Xiaoying Shang ,Jiexi Li ,Zheng D Lan ,Shan Jiang ,Kayla Nutsch ,Brittney A Beyer ,Luke L Lairson ,Adam T Boutin ,Michael J Bollong ,Peter G Schultz ,Ronald A DePinho

JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma

JAK抑制剂可增强霍奇金淋巴瘤患者的免疫检查点阻断疗法。

Jaroslav Zak ,Isaraphorn Pratumchai ,Brett S Marro ,Kristi L Marquardt ,Reza Beheshti Zavareh ,Luke L Lairson ,Michael B A Oldstone ,Judith A Varner ,Livia Hegerova ,Qing Cao ,Umar Farooq ,Vaishalee P Kenkre ,Veronika Bachanova # ,John R Teijaro #

Synthesis of portimines reveals the basis of their anti-cancer activity

合成波特明揭示了其抗癌活性的基础

Junchen Tang #,Weichao Li #,Tzu-Yuan Chiu,Francisco Martínez-Peña,Zengwei Luo,Christine T Chong,Qijia Wei,Nathalia Gazaniga,Thomas J West,Yi Yang See,Luke L Lairson,Christopher G Parker,Phil S Baran

Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A

化学蛋白质组学揭示微生物衍生的 GPRC5A 芳香族单胺激动剂

Xiaohui Zhao, Kathryn R Stein, Victor Chen, Matthew E Griffin, Luke L Lairson, Howard C Hang

Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas

稳定波形蛋白磷酸化可抑制混合型上皮/间质癌的干细胞样特性和转移。

Nick A Kuburich ,Petra den Hollander ,Maria Castaneda ,Mika Pietilä ,Ximing Tang ,Harsh Batra ,Francisco Martínez-Peña ,Tanvi H Visal ,Tieling Zhou ,Breanna R Demestichas ,Ritesh V Dontula ,Jojo Y Liu ,Joanna Joyce Maddela ,Reethi S Padmanabhan ,Lan Thi Hanh Phi ,Matthew J Rosolen ,Thiru Sabapathy ,Dhiraj Kumar ,Filippo G Giancotti ,Luke L Lairson ,Maria Gabriela Raso ,Rama Soundararajan ,Sendurai A Mani

Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux

羟脯氨酸代谢增强IFN-γ诱导的PD-L1表达并抑制自噬通量

Stephan H Spangenberg ,Amelia Palermo ,Nathalia R Gazaniga ,Francisco Martínez-Peña ,Carlos Guijas ,Emily N Chin ,Markus M Rinschen ,Philipp N Sander ,Bill Webb ,Laura E Pereira ,Ying Jia ,Lance Meitz ,Gary Siuzdak ,Luke L Lairson

Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers

新型 FiVe1 衍生物作为治疗间充质癌症的有效选择性药物的合成和生物学评价

Francisco Martínez-Peña, Aaron D Pearson, Eileen L Tang, Nick A Kuburich, Sendurai A Mani, Peter G Schultz, Michael J Bollong, Luke L Lairson

HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins

HSP90 抑制可通过调节多种免疫检查点蛋白的表面表达来增强癌症免疫治疗

Reza Beheshti Zavareh, Stephan H Spangenberg, Ashley Woods, Francisco Martínez-Peña, Luke L Lairson

Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay

合成荧光 MYC 探针:抑制剂结合位点阐明和高通量筛选试验的开发

Ryan J Shirey, Jonathan R Hart, BanuPriya Sridharan, Scott J Novick, Lewis D Turner, Bin Zhou, Alexander L Nielsen, Lisa M Eubanks, Lynn Ueno, Mark S Hixon, Luke L Lairson, Timothy P Spicer, Louis D Scampavia, Patrick R Griffin, Peter K Vogt, Kim D Janda

Protocol for high-throughput compound screening using flow cytometry in THP-1 cells

使用流式细胞术在 THP-1 细胞中进行高通量化合物筛选的方案

Stephan H Spangenberg, Reza Beheshti Zavareh, Luke L Lairson