日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia

全基因组 CRISPR/Cas9 缺失筛选确定了线粒体基因的必要性并确定了肿瘤细胞在缺氧条件下存活的途径

Luke W Thomas #, Cinzia Esposito #, Rachel E Morgan, Stacey Price, Jamie Young, Steven P Williams, Lucas A Maddalena, Ultan McDermott, Margaret Ashcroft

Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress

增强的肝脏呼吸能力和改变的脂质代谢支持短期缺氧应激期间的代谢稳态

Katie A O'Brien, Ben D McNally, Alice P Sowton, Antonio Murgia, James Armitage, Luke W Thomas, Fynn N Krause, Lucas A Maddalena, Ian Francis, Stefan Kavanagh, Dominic P Williams, Margaret Ashcroft, Julian L Griffin, Jonathan J Lyon, Andrew J Murray

CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism

CHCHD4 通过呼吸链介导的代谢调节肿瘤增殖和 EMT 相关表型

Luke W Thomas, Cinzia Esposito, Jenna M Stephen, Ana S H Costa, Christian Frezza, Thomas S Blacker, Gyorgy Szabadkai, Margaret Ashcroft

CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain

CHCHD4 通过控制线粒体呼吸链赋予肿瘤细胞代谢脆弱性

Luke W Thomas, Jenna M Stephen, Cinzia Esposito, Simon Hoer, Robin Antrobus, Afshan Ahmed, Hasan Al-Habib, Margaret Ashcroft

The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo

线粒体氧化还原酶 CHCHD4 在体内处于半氧化状态

Alican J Erdogan, Muna Ali, Markus Habich, Silja L Salscheider, Laura Schu, Carmelina Petrungaro, Luke W Thomas, Margaret Ashcroft, Lars I Leichert, Leticia Prates Roma, Jan Riemer

VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function

VHL 介导的 CHCHD4 和线粒体功能的调节

Thomas Briston, Jenna M Stephen, Luke W Thomas, Cinzia Esposito, Yuen-Li Chung, Saiful E Syafruddin, Mark Turmaine, Lucas A Maddalena, Basma Greef, Gyorgy Szabadkai, Patrick H Maxwell, Sakari Vanharanta, Margaret Ashcroft

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

人类 CHCHD4 线粒体蛋白调节细胞耗氧率和代谢,在缺氧信号和肿瘤进展中发挥关键作用

Jun Yang, Oliver Staples, Luke W Thomas, Thomas Briston, Mathew Robson, Evon Poon, Maria L Simões, Ethaar El-Emir, Francesca M Buffa, Afshan Ahmed, Nicholas P Annear, Deepa Shukla, Barbara R Pedley, Patrick H Maxwell, Adrian L Harris, Margaret Ashcroft