日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

利用预测结构和数据挖掘技术重新审视恶性疟原虫可药物靶向基因组

Godinez-Macias, Karla P; Chen, Daisy; Wallis, J Lincoln; Siegel, Miles G; Adam, Anna; Bopp, Selina; Carolino, Krypton; Coulson, Lauren B; Durst, Greg; Thathy, Vandana; Esherick, Lisl; Farringer, Madeline A; Flannery, Erika L; Forte, Barbara; Liu, Tiqing; Godoy Magalhaes, Luma; Gupta, Anil K; Istvan, Eva S; Jiang, Tiantian; Kumpornsin, Krittikorn; Lobb, Karen; McLean, Kyle J; Moura, Igor M R; Okombo, John; Payne, N Connor; Plater, Andrew; Rao, Srinivasa P S; Siqueira-Neto, Jair L; Somsen, Bente A; Summers, Robert L; Zhang, Rumin; Gilson, Michael K; Gamo, Francisco-Javier; Campo, Brice; Baragaña, Beatriz; Duffy, James; Gilbert, Ian H; Lukens, Amanda K; Dechering, Koen J; Niles, Jacquin C; McNamara, Case W; Cheng, Xiu; Birkholtz, Lyn-Marie; Bronkhorst, Alfred W; Fidock, David A; Wirth, Dyann F; Goldberg, Daniel E; Lee, Marcus C S; Winzeler, Elizabeth A

Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in Plasmodium HSP90 Inhibitors

疟原虫HSP90抑制剂的共同结合位点和不同的耐药谱揭示了新的耐药机制

Ko, Fu-Hsuan; Lukens, Amanda K; de Souza, Mariana Laureano; Foy, Alex; Hsiao, Jason; Ndiaye, Tolla; Okombo, John; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Boonyalai, Nonlawat; Kumpornsin, Krittikorn; Girling, Gareth; Pasaje, Charisse; Godoy, Luiz; Ottilie, Sabine; Durst, Gregory L; Chatterjee, Arnab; Niles, Jacquin; Lee, Marcus; Fidock, David A; Wirth, Dyann F; Winzeler, Elizabeth A

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A

Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance

酿酒酵母的适应性实验室进化凸显了转录因子在真菌异生物质抗性中的作用

Ottilie, Sabine; Luth, Madeline R; Hellemann, Erich; Goldgof, Gregory M; Vigil, Eddy; Kumar, Prianka; Cheung, Andrea L; Song, Miranda; Godinez-Macias, Karla P; Carolino, Krypton; Yang, Jennifer; Lopez, Gisel; Abraham, Matthew; Tarsio, Maureen; LeBlanc, Emmanuelle; Whitesell, Luke; Schenken, Jake; Gunawan, Felicia; Patel, Reysha; Smith, Joshua; Love, Melissa S; Williams, Roy M; McNamara, Case W; Gerwick, William H; Ideker, Trey; Suzuki, Yo; Wirth, Dyann F; Lukens, Amanda K; Kane, Patricia M; Cowen, Leah E; Durrant, Jacob D; Winzeler, Elizabeth A

MalDA, Accelerating Malaria Drug Discovery

MalDA,加速疟疾药物研发

Yang, Tuo; Ottilie, Sabine; Istvan, Eva S; Godinez-Macias, Karla P; Lukens, Amanda K; Baragaña, Beatriz; Campo, Brice; Walpole, Chris; Niles, Jacquin C; Chibale, Kelly; Dechering, Koen J; Llinás, Manuel; Lee, Marcus C S; Kato, Nobutaka; Wyllie, Susan; McNamara, Case W; Gamo, Francisco Javier; Burrows, Jeremy; Fidock, David A; Goldberg, Daniel E; Gilbert, Ian H; Wirth, Dyann F; Winzeler, Elizabeth A

Prioritization of Molecular Targets for Antimalarial Drug Discovery

抗疟药物研发中分子靶点的优先排序

Forte, Barbara; Ottilie, Sabine; Plater, Andrew; Campo, Brice; Dechering, Koen J; Gamo, Francisco Javier; Goldberg, Daniel E; Istvan, Eva S; Lee, Marcus; Lukens, Amanda K; McNamara, Case W; Niles, Jacquin C; Okombo, John; Pasaje, Charisse Flerida A; Siegel, Miles G; Wirth, Dyann; Wyllie, Susan; Fidock, David A; Baragaña, Beatriz; Winzeler, Elizabeth A; Gilbert, Ian H

Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections

作者更正:理解和治疗活动性和慢性、持续性顶复门感染的新范式及突破性进展

McPhillie, Martin; Zhou, Ying; El Bissati, Kamal; Dubey, Jitender; Lorenzi, Hernan; Capper, Michael; Lukens, Amanda K; Hickman, Mark; Muench, Stephen; Verma, Shiv Kumar; Weber, Christopher R; Wheeler, Kelsey; Gordon, James; Sanders, Justin; Moulton, Hong; Wang, Kai; Kim, Taek-Kyun; He, Yuqing; Santos, Tatiana; Woods, Stuart; Lee, Patty; Donkin, David; Kim, Eric; Fraczek, Laura; Lykins, Joseph; Esaa, Farida; Alibana-Clouser, Fatima; Dovgin, Sarah; Weiss, Louis; Brasseur, Gael; Wirth, Dyann; Kent, Michael; Hood, Leroy; Meunieur, Brigitte; Roberts, Craig W; Hasnain, S Samar; Antonyuk, Svetlana V; Fishwick, Colin; McLeod, Rima

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

利用开源方式发现下一代化学保护性抗疟药物的先导化合物

Antonova-Koch, Yevgeniya; Meister, Stephan; Abraham, Matthew; Luth, Madeline R; Ottilie, Sabine; Lukens, Amanda K; Sakata-Kato, Tomoyo; Vanaerschot, Manu; Owen, Edward; Jado, Juan Carlos; Maher, Steven P; Calla, Jaeson; Plouffe, David; Zhong, Yang; Chen, Kaisheng; Chaumeau, Victor; Conway, Amy J; McNamara, Case W; Ibanez, Maureen; Gagaring, Kerstin; Serrano, Fernando Neria; Eribez, Korina; Taggard, Cullin McLean; Cheung, Andrea L; Lincoln, Christie; Ambachew, Biniam; Rouillier, Melanie; Siegel, Dionicio; Nosten, François; Kyle, Dennis E; Gamo, Francisco-Javier; Zhou, Yingyao; Llinás, Manuel; Fidock, David A; Wirth, Dyann F; Burrows, Jeremy; Campo, Brice; Winzeler, Elizabeth A

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

多样性导向合成产生新型多阶段抗疟疾抑制剂

Kato Nobutaka, Comer Eamon, Sakata-Kato Tomoyo, Sharma Arvind, Sharma Manmohan, Maetani Micah, Bastien Jessica, Brancucci Nicolas M, Bittker Joshua A, Corey Victoria, Clarke David, Derbyshire Emily R, Dornan Gillian L, Duffy Sandra, Eckley Sean, Itoe Maurice A, Koolen Karin M J, Lewis Timothy A, Lui Ping S, Lukens Amanda K, Lund Emily, March Sandra, Meibalan Elamaran, Meier Bennett C, McPhail Jacob A, Mitasev Branko, Moss Eli L, Sayes Morgane, Van Gessel Yvonne, Wawer Mathias J, Yoshinaga Takashi, Zeeman Anne-Marie, Avery Vicky M, Bhatia Sangeeta N, Burke John E, Catteruccia Flaminia, Clardy Jon C, Clemons Paul A, Dechering Koen J, Duvall Jeremy R, Foley Michael A, Gusovsky Fabian, Kocken Clemens H M, Marti Matthias, Morningstar Marshall L, Munoz Benito, Neafsey Daniel E, Sharma Amit, Winzeler Elizabeth A, Wirth Dyann F, Scherer Christina A, Schreiber Stuart L

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

三氨基嘧啶是一种速效且长效的抗疟疾候选药物。

Hameed P, Shahul; Solapure, Suresh; Patil, Vikas; Henrich, Philipp P; Magistrado, Pamela A; Bharath, Sowmya; Murugan, Kannan; Viswanath, Pavithra; Puttur, Jayashree; Srivastava, Abhishek; Bellale, Eknath; Panduga, Vijender; Shanbag, Gajanan; Awasthy, Disha; Landge, Sudhir; Morayya, Sapna; Koushik, Krishna; Saralaya, Ramanatha; Raichurkar, Anandkumar; Rautela, Nikhil; Roy Choudhury, Nilanjana; Ambady, Anisha; Nandishaiah, Radha; Reddy, Jitendar; Prabhakar, K R; Menasinakai, Sreenivasaiah; Rudrapatna, Suresh; Chatterji, Monalisa; Jiménez-Díaz, María Belén; Martínez, María Santos; Sanz, Laura María; Coburn-Flynn, Olivia; Fidock, David A; Lukens, Amanda K; Wirth, Dyann F; Bandodkar, Balachandra; Mukherjee, Kakoli; McLaughlin, Robert E; Waterson, David; Rosenbrier-Ribeiro, Lyn; Hickling, Kevin; Balasubramanian, V; Warner, Peter; Hosagrahara, Vinayak; Dudley, Adam; Iyer, Pravin S; Narayanan, Shridhar; Kavanagh, Stefan; Sambandamurthy, Vasan K