Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)]
将三个环外精氨酸残基掺入黑皮质素大环激动剂（c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]）中，与缺乏环外精氨酸残基的大环配体（c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]）相比，鞘内或皮下注射该激动剂可降低食物摄入量。
期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.4c00011
Ericson, Mark D; Freeman, Katie T; Larson, Courtney M; Bouchard, Jacob L; John, Kristen; Lunzer, Mary M; Koerperich, Zoe M; Haskell-Luevano, Carrie
