Discovery of 5-imidazole-3-methylbenz[d]isoxazole derivatives as potent and selective CBP/p300 bromodomain inhibitors for the treatment of acute myeloid leukemia.
发现 5-咪唑-3-甲基苯并[d]异恶唑衍生物是治疗急性髓系白血病的强效选择性 CBP/p300 溴结构域抑制剂
期刊:Acta Pharmacologica Sinica
影响因子:8.4
doi:10.1038/s41401-025-01478-x
Hu Jian-Kang, Tang Xin, Luo Guo-Long, Zhang Cheng, Wu Tian-Bang, Wang Chao, Shen Hui, Zhao Xiao-Fan, Wu Xi-Shan, Smaill Jeff B, Xu Yong, Zhang Yan, Xiang Qiu-Ping
