The LRRK2 P1446L mutation triggers dopaminergic neurodegeneration via DAPK1-mediated microglial neuroinflammation and neuronal apoptosis.
LRRK2 P1446L 突变通过 DAPK1 介导的小胶质细胞神经炎症和神经元凋亡引发多巴胺能神经退行性变。
期刊:Npj Parkinsons Disease
影响因子:8.2
doi:10.1038/s41531-025-01234-2
Ding Liuyan, Shu Hui, Chen Minshan, Liang Fengchu, Gan Tingting, Huang Xingting, Liang Xiaolei, Luo Kangting, Qiu Linfeng, Huang Weiqing, Zhu Xiaoqin, Huang Xiaoyun, Zhang Wenlong, Xu Pingyi
神经炎症
细胞生物学
神经科学
胶质细胞
DAPK1
LRRK2
Apoptosis
Immunology/Inflammation
炎症
凋亡
