日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

De-coupling immune parameters and toxicity associated with IL-12 agonism

IL-12激动剂相关免疫参数和毒性的解耦

Zachary R Lanzar ,Daniel L Aldridge ,Bhargavi Jayaraman ,Breanne Haskins ,Christian A Howard ,Kathya Arana ,Molly E Bunkofske ,Kathleen Mulka ,Ryan D Pardy ,Jessica Byerly ,Boris Striepen ,Patrick Lupardus ,Christopher A Hunter

Structure-Guided Stapling of Dimeric Conformations and Linker Engineering Enhance Thermostability and Fine-Tune Activity of Bispecific VHH Cytokine Agonists.

结构导向的二聚体构象交联和连接子工程增强了双特异性 VHH 细胞因子激动剂的热稳定性并微调了其活性

Trenker Raphael, Rokkam Deepti, Morin Andrew, Balasubrahmanyam Priyanka, Paredes Verenice, Cheng Ivan, de Waal Malefyt Rene, Oft Martin, Lupardus Patrick, Vivona Sandro

Mössbauer and EPR detection of iron trafficking kinetics and possibly labile iron pools in whole Saccharomyces cerevisiae cells

利用穆斯堡尔谱和电子顺磁共振技术检测酿酒酵母全细胞中铁转运动力学以及可能的活性铁池

Delanoy, Grant; Lupardus, Cody; Vali, Shaik Waseem; Wofford, Joshua D; Thorat, Shantanu; Lindahl, Paul A

Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer

用于治疗结直肠癌的新型抗LY6G6D/CD3 T细胞依赖性双特异性抗体

Peiyin Wang #, Liping L Sun #, Robyn Clark, Maria Hristopoulos, Cecilia P C Chiu, Michael Dillon, WeiYu Lin, Amy A Lo, Sreedevi Chalsani, Meghna Das Thakur, Kristin M Zimmerman Savill, Lionel Rougé, Patrick Lupardus, Robert Piskol, Bushra Husain, Diego Ellerman, Vittal Shivva, Steven R Leong, Meric

Kinase inhibition in autoimmunity and inflammation

激酶抑制在自身免疫和炎症中的作用

Zarrin, Ali A; Bao, Katherine; Lupardus, Patrick; Vucic, Domagoj

Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

IL-12 和 IL-23 受体共享的结构基础揭示了塑造 T 细胞与 NK 细胞作用的途径

Caleb R Glassman, Yamuna Kalyani Mathiharan, Kevin M Jude, Leon Su, Ouliana Panova, Patrick J Lupardus, Jamie B Spangler, Lauren K Ely, Christoph Thomas, Georgios Skiniotis, K Christopher Garcia

Dramatic activation of an antibody by a single amino acid change in framework

抗体骨架中单个氨基酸的改变即可显著激活

Wei-Ching Liang, Jianping Yin, Patrick Lupardus, Jianhuan Zhang, Kelly M Loyet, Jawahar Sudhamsu, Yan Wu

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

RIP1 抑制可阻止炎症性疾病,但不能阻止肿瘤生长或转移

Snahel Patel, Joshua D Webster, Eugene Varfolomeev, Youngsu C Kwon, Jason H Cheng, Juan Zhang, Debra L Dugger, Kate E Wickliffe, Allie Maltzman, Swathi Sujatha-Bhaskar, Pawan Bir Kohli, Sreema Ramaswamy, Gauri Deshmukh, Bianca M Liederer, Rina Fong, Greg Hamilton, Patrick Lupardus, Patrick Caplazi, 

Mutation position is an important determinant for predicting cancer neoantigens

突变位置是预测癌症新抗原的重要决定因素。

Aude-Hélène Capietto # ,Suchit Jhunjhunwala # ,Samuel B Pollock ,Patrick Lupardus ,Jim Wong ,Lena Hänsch ,James Cevallos ,Yajun Chestnut ,Ajay Fernandez ,Nicolas Lounsbury ,Tamaki Nozawa ,Manmeet Singh ,Zhiyuan Fan ,Cecile C de la Cruz ,Qui T Phung ,Lucia Taraborrelli ,Benjamin Haley ,Jennie R Lill ,Ira Mellman ,Richard Bourgon ,Lélia Delamarre

Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity

发现具有强效体内活性的苯并内酰胺类IRAK4抑制剂

Rajapaksa, Naomi S; Gobbi, Alberto; Drobnick, Joy; Do, Steven; Kolesnikov, Aleksandr; Liang, Jun; Chen, Yongsheng; Sujatha-Bhaskar, Swathi; Huang, Zhiyu; Brightbill, Hans; Francis, Ross; Yu, Christine; Choo, Edna F; DeMent, Kevin; Ran, Yingqing; An, Le; Emson, Claire; Maher, Jonathan; Wai, John; McKenzie, Brent S; Lupardus, Patrick J; Zarrin, Ali A; Kiefer, James R; Bryan, Marian C