日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-Guided Stapling of Dimeric Conformations and Linker Engineering Enhance Thermostability and Fine-Tune Activity of Bispecific VHH Cytokine Agonists.

结构导向的二聚体构象交联和连接子工程增强了双特异性 VHH 细胞因子激动剂的热稳定性并微调了其活性

Trenker Raphael, Rokkam Deepti, Morin Andrew, Balasubrahmanyam Priyanka, Paredes Verenice, Cheng Ivan, de Waal Malefyt Rene, Oft Martin, Lupardus Patrick, Vivona Sandro

Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation

Janus激酶细胞因子受体复合物的结构揭示了二聚体激活的基础

Glassman, Caleb R; Tsutsumi, Naotaka; Saxton, Robert A; Lupardus, Patrick J; Jude, Kevin M; Garcia, K Christopher

Kinase inhibition in autoimmunity and inflammation

激酶抑制在自身免疫和炎症中的作用

Zarrin, Ali A; Bao, Katherine; Lupardus, Patrick; Vucic, Domagoj

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

RIP1 抑制可阻止炎症性疾病,但不能阻止肿瘤生长或转移

Snahel Patel, Joshua D Webster, Eugene Varfolomeev, Youngsu C Kwon, Jason H Cheng, Juan Zhang, Debra L Dugger, Kate E Wickliffe, Allie Maltzman, Swathi Sujatha-Bhaskar, Pawan Bir Kohli, Sreema Ramaswamy, Gauri Deshmukh, Bianca M Liederer, Rina Fong, Greg Hamilton, Patrick Lupardus, Patrick Caplazi, 

Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity

发现具有强效体内活性的苯并内酰胺类IRAK4抑制剂

Rajapaksa, Naomi S; Gobbi, Alberto; Drobnick, Joy; Do, Steven; Kolesnikov, Aleksandr; Liang, Jun; Chen, Yongsheng; Sujatha-Bhaskar, Swathi; Huang, Zhiyu; Brightbill, Hans; Francis, Ross; Yu, Christine; Choo, Edna F; DeMent, Kevin; Ran, Yingqing; An, Le; Emson, Claire; Maher, Jonathan; Wai, John; McKenzie, Brent S; Lupardus, Patrick J; Zarrin, Ali A; Kiefer, James R; Bryan, Marian C

The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions

Janus激酶(JAK)的FERM和SH2结构域:赋予JAK-受体相互作用特异性

Ferrao, Ryan; Lupardus, Patrick J

The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

JAK1识别II类细胞因子受体的结构基础

Ferrao, Ryan; Wallweber, Heidi J A; Ho, Hoangdung; Tam, Christine; Franke, Yvonne; Quinn, John; Lupardus, Patrick J

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

酪氨酸激酶2识别干扰素-α受体的结构基础

Wallweber, Heidi J A; Tam, Christine; Franke, Yvonne; Starovasnik, Melissa A; Lupardus, Patrick J

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

定义艰难梭菌毒素半胱氨酸蛋白酶结构域中的变构回路

Shen, Aimee; Lupardus, Patrick J; Gersch, Malte M; Puri, Aaron W; Albrow, Victoria E; Garcia, K Christopher; Bogyo, Matthew

Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB

针对艰难梭菌毒力因子TcdB的抑制剂和活性探针的合理设计

Puri, Aaron W; Lupardus, Patrick J; Deu, Edgar; Albrow, Victoria E; Garcia, K Christopher; Bogyo, Matthew; Shen, Aimee