日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic insights into dual-active liver and blood-stage antiplasmodials

对具有双重活性的肝期和血期抗疟药物的机制研究

Rawat, Mukul; Boonyalai, Nonlawat; Smidt, Cindy; Luth, Madeline R; Chen, Daisy; Plater, Andrew; Post, John; Lin, De; McMillan, Joel; Eadsforth, Thomas; Moliner-Cubel, Sonia; Billker, Oliver; Rayner, Julian C; Gamo, Fransisco-Javier; Baragaña, Beatriz; Winzeler, Elizabeth A; Lee, Marcus C S

Mechanistic Insights into Dual-Active Liver and Blood-Stage Antiplasmodials.

对具有双重活性的肝期和血期抗疟药物的机制研究

Rawat Mukul, Boonyalai Nonlawat, Smidt Cindy, Luth Madeline R, Chen Daisy, Plater Andrew, Post John, Lin De, McMillan Joel, Eadsforth Thomas, Moliner-Cubel Sonia, Billker Oliver, Rayner Julian C, Gamo Francisco-Javier, Baragaña Beatriz, Winzeler Elizabeth A, Lee Marcus C S

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

恶性疟原虫天冬酰胺tRNA合成酶的反应劫持抑制

Xie, Stanley C; Wang, Yinuo; Morton, Craig J; Metcalfe, Riley D; Dogovski, Con; Pasaje, Charisse Flerida A; Dunn, Elyse; Luth, Madeline R; Kumpornsin, Krittikorn; Istvan, Eva S; Park, Joon Sung; Fairhurst, Kate J; Ketprasit, Nutpakal; Yeo, Tomas; Yildirim, Okan; Bhebhe, Mathamsanqa N; Klug, Dana M; Rutledge, Peter J; Godoy, Luiz C; Dey, Sumanta; De Souza, Mariana Laureano; Siqueira-Neto, Jair L; Du, Yawei; Puhalovich, Tanya; Amini, Mona; Shami, Gerry; Loesbanluechai, Duangkamon; Nie, Shuai; Williamson, Nicholas; Jana, Gouranga P; Maity, Bikash C; Thomson, Patrick; Foley, Thomas; Tan, Derek S; Niles, Jacquin C; Han, Byung Woo; Goldberg, Daniel E; Burrows, Jeremy; Fidock, David A; Lee, Marcus C S; Winzeler, Elizabeth A; Griffin, Michael D W; Todd, Matthew H; Tilley, Leann

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

酪氨酸tRNA合成酶的反应劫持作为一种新的全生命周期抗疟策略

Xie, Stanley C; Metcalfe, Riley D; Dunn, Elyse; Morton, Craig J; Huang, Shih-Chung; Puhalovich, Tanya; Du, Yawei; Wittlin, Sergio; Nie, Shuai; Luth, Madeline R; Ma, Liting; Kim, Mi-Sook; Pasaje, Charisse Flerida A; Kumpornsin, Krittikorn; Giannangelo, Carlo; Houghton, Fiona J; Churchyard, Alisje; Famodimu, Mufuliat T; Barry, Daniel C; Gillett, David L; Dey, Sumanta; Kosasih, Clara C; Newman, William; Niles, Jacquin C; Lee, Marcus C S; Baum, Jake; Ottilie, Sabine; Winzeler, Elizabeth A; Creek, Darren J; Williamson, Nicholas; Parker, Michael W; Brand, Stephen; Langston, Steven P; Dick, Lawrence R; Griffin, Michael D W; Gould, Alexandra E; Tilley, Leann

Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance

酿酒酵母的适应性实验室进化凸显了转录因子在真菌异生物质抗性中的作用

Ottilie, Sabine; Luth, Madeline R; Hellemann, Erich; Goldgof, Gregory M; Vigil, Eddy; Kumar, Prianka; Cheung, Andrea L; Song, Miranda; Godinez-Macias, Karla P; Carolino, Krypton; Yang, Jennifer; Lopez, Gisel; Abraham, Matthew; Tarsio, Maureen; LeBlanc, Emmanuelle; Whitesell, Luke; Schenken, Jake; Gunawan, Felicia; Patel, Reysha; Smith, Joshua; Love, Melissa S; Williams, Roy M; McNamara, Case W; Gerwick, William H; Ideker, Trey; Suzuki, Yo; Wirth, Dyann F; Lukens, Amanda K; Kane, Patricia M; Cowen, Leah E; Durrant, Jacob D; Winzeler, Elizabeth A

The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite

新型双-1,2,4-三嗪化合物MIPS-0004373对疟原虫所有血液阶段均表现出快速而强效的活性

Ellis, Katherine M; Lucantoni, Leonardo; Chavchich, Marina; Abraham, Matthew; De Paoli, Amanda; Luth, Madeline R; Zeeman, Anne-Marie; Delves, Michael J; Terán, Fernando Sánchez-Román; Straschil, Ursula; Baum, Jake; Kocken, Clemens H M; Ralph, Stuart A; Winzeler, Elizabeth A; Avery, Vicky M; Edstein, Michael D; Baell, Jonathan B; Creek, Darren J

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

共价结合的恶性疟原虫选择性蛋白酶体抑制剂在体外产生耐药性的倾向较低,并且能与多种抗疟药物产生协同作用。

Stokes, Barbara H; Yoo, Euna; Murithi, James M; Luth, Madeline R; Afanasyev, Pavel; da Fonseca, Paula C A; Winzeler, Elizabeth A; Ng, Caroline L; Bogyo, Matthew; Fidock, David A

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

利用开源方式发现下一代化学保护性抗疟药物的先导化合物

Antonova-Koch, Yevgeniya; Meister, Stephan; Abraham, Matthew; Luth, Madeline R; Ottilie, Sabine; Lukens, Amanda K; Sakata-Kato, Tomoyo; Vanaerschot, Manu; Owen, Edward; Jado, Juan Carlos; Maher, Steven P; Calla, Jaeson; Plouffe, David; Zhong, Yang; Chen, Kaisheng; Chaumeau, Victor; Conway, Amy J; McNamara, Case W; Ibanez, Maureen; Gagaring, Kerstin; Serrano, Fernando Neria; Eribez, Korina; Taggard, Cullin McLean; Cheung, Andrea L; Lincoln, Christie; Ambachew, Biniam; Rouillier, Melanie; Siegel, Dionicio; Nosten, François; Kyle, Dennis E; Gamo, Francisco-Javier; Zhou, Yingyao; Llinás, Manuel; Fidock, David A; Wirth, Dyann F; Burrows, Jeremy; Campo, Brice; Winzeler, Elizabeth A