Age-associated increases in PAI-1 silenced with siRNA-lipid nanoparticles reduces thrombosis and prolongs lifespan
利用siRNA-脂质纳米颗粒沉默PAI-1可降低血栓形成并延长寿命,而PAI-1的年龄相关性增加则可减少血栓形成并延长寿命。
期刊:Blood
影响因子:23.1
doi:10.1182/blood.2025029834
Ferraresso, Francesca; Skaer, Chad W; Wei, Zimu; Paul, Manoj; Hur, Woosuk Steve; Yu, Hongyin; Seadler, Monica; Chen, Taylor H Y; Dai, Wen; Lapointe, Catherine; Ketelboeter, Laura M; Lund, Hayley; Rodriguez, Geoffrey G; Juang, Lih Jiin; Strilchuk, Amy W; Zhang, Youjie; Cullis, Pieter R; Dyer, Mitchell R; Gerras, Allison L; Shi, Qizhen; Luyendyk, James P; Flick, Matthew J; Kastrup, Christian J