日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy.

对影响完全化学修饰的siRNA功效的siRNA和mRNA特征进行系统分析

Davis Sarah M, Hildebrand Samuel, MacMillan Hannah J, Monopoli Kathryn R, Buchwald Julianna, Sousa Jacquelyn, Cooper David, Ly Socheata, Echeverria Dimas, McHugh Nicholas, Ferguson Chantal, Coles Andrew, Hariharan Vignesh N, O'Reilly Daniel, Tang Qi, Furgal Raymond, Yamada Ken, Alterman Julia F, Gilbert James W, Knox Emily, Pineda Yamilett, Weston Caitlyn N, Baer Christina E, Pai Athma A, Khvorova Anastasia

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease

二价siRNA介导的MSH3沉默可阻断亨廷顿病小鼠模型中的体细胞重复序列扩增

O'Reilly, Daniel; Belgrad, Jillian; Ferguson, Chantal; Summers, Ashley; Sapp, Ellen; McHugh, Cassandra; Mathews, Ella; Boudi, Adel; Buchwald, Julianna; Ly, Socheata; Moreno, Dimas; Furgal, Raymond; Luu, Eric; Kennedy, Zachary; Hariharan, Vignesh; Monopoli, Kathryn; Yang, X William; Carroll, Jeffery; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains

突变型亨廷顿蛋白信使RNA在啮齿动物和人类大脑中形成神经元核簇

Ly, Socheata; Didiot, Marie-Cécile; Ferguson, Chantal M; Coles, Andrew H; Miller, Rachael; Chase, Kathryn; Echeverria, Dimas; Wang, Feng; Sadri-Vakili, Ghazaleh; Aronin, Neil; Khvorova, Anastasia

Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo

新型簇状和单体状 GalNAc 结构可诱导 siRNA 在体外和体内的有效吸收

Sharma, Vivek K; Osborn, Maire F; Hassler, Matthew R; Echeverria, Dimas; Ly, Socheata; Ulashchik, Egor A; Martynenko-Makaev, Yury V; Shmanai, Vadim V; Zatsepin, Timofei S; Khvorova, Anastasia; Watts, Jonathan K

Tropomyosin is in a reduced state in rabbit psoas muscle

兔腰大肌中的原肌球蛋白处于还原状态

Lehrer, Sherwin S; Ly, Socheata; Fuchs, Franklin