日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4

兔窦房结细胞的基础自发放电受磷酸二酯酶(PDE)3和4的双重激活调控

Vinogradova, Tatiana M; Sirenko, Syevda; Lukyanenko, Yevgeniya O; Yang, Dongmei; Tarasov, Kirill V; Lyashkov, Alexey E; Varghese, Nevin J; Li, Yue; Chakir, Khalid; Ziman, Bruce; Lakatta, Edward G

Ca(2+)/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function

Ca(2+)/钙调蛋白激活的磷酸二酯酶1A在兔心脏窦房结细胞中高表达,并调节起搏器功能。

Lukyanenko, Yevgeniya O; Younes, Antoine; Lyashkov, Alexey E; Tarasov, Kirill V; Riordon, Daniel R; Lee, Joonho; Sirenko, Syevda G; Kobrinsky, Evgeny; Ziman, Bruce; Tarasova, Yelena S; Juhaszova, Magdalena; Sollott, Steven J; Graham, David R; Lakatta, Edward G

Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cells

心脏起搏细胞中PKA生化信号网络动态与动作电位发放频率增加的实时关系:心脏起搏细胞中PKA激活的动力学

Yaniv, Yael; Ganesan, Ambhighainath; Yang, Dongmei; Ziman, Bruce D; Lyashkov, Alexey E; Levchenko, Andre; Zhang, Jin; Lakatta, Edward G

Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate

对心率变异性和心率之间未被充分重视但又十分重要的关系进行生物物理学表征

Monfredi, Oliver; Lyashkov, Alexey E; Johnsen, Anne-Berit; Inada, Shin; Schneider, Heiko; Wang, Ruoxi; Nirmalan, Mahesh; Wisloff, Ulrik; Maltsev, Victor A; Lakatta, Edward G; Zhang, Henggui; Boyett, Mark R

Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals

窦房结起搏细胞时钟的同步及其自主调节使心跳间隔变得复杂。

Yaniv, Yael; Ahmet, Ismayil; Liu, Jie; Lyashkov, Alexey E; Guiriba, Toni-Rose; Okamoto, Yosuke; Ziman, Bruce D; Lakatta, Edward G

Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells

耦合时钟机制固有的随机性是窦房结起搏细胞自发动作电位发放逐搏变异性的根本原因。

Yaniv, Yael; Lyashkov, Alexey E; Sirenko, Syevda; Okamoto, Yosuke; Guiriba, Toni-Rose; Ziman, Bruce D; Morrell, Christopher H; Lakatta, Edward G

Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease

窦房结起搏细胞固有信号传导受损会影响心脏疾病期间的心率变异性。

Yaniv, Yael; Lyashkov, Alexey E; Lakatta, Edward G

Ca²⁺-dependent phosphorylation of Ca²⁺ cycling proteins generates robust rhythmic local Ca²⁺ releases in cardiac pacemaker cells

心脏起搏细胞中钙离子循环蛋白的钙离子依赖性磷酸化可产生强劲的节律性局部钙离子释放。

Sirenko, Syevda; Yang, Dongmei; Li, Yue; Lyashkov, Alexey E; Lukyanenko, Yevgeniya O; Lakatta, Edward G; Vinogradova, Tatiana M

The fractal-like complexity of heart rate variability beyond neurotransmitters and autonomic receptors: signaling intrinsic to sinoatrial node pacemaker cells

心率变异性的分形复杂性超越了神经递质和自主神经受体:窦房结起搏细胞的内在信号传导

Yaniv, Yael; Lyashkov, Alexey E; Lakatta, Edward G

RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells

RGS2 过表达或 G(i) 抑制可挽救培养的成年兔起搏细胞中受损的 PKA 信号传导和缓慢的动作电位发放。

Yang, Dongmei; Lyashkov, Alexey E; Li, Yue; Ziman, Bruce D; Lakatta, Edward G