日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural mechanism of a drug-binding process involving a large conformational change of the protein target

药物结合过程的结构机制,涉及靶蛋白的大幅构象变化

Pelin Ayaz # ,Agatha Lyczek # ,YiTing Paung ,Victoria R Mingione ,Roxana E Iacob ,Parker W de Waal ,John R Engen ,Markus A Seeliger ,Yibing Shan ,David E Shaw

The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly

HAX1 蛋白的 RNA 结合情况表明其参与翻译和核糖体组装

Anna Balcerak, Ewelina Macech-Klicka, Maciej Wakula, Rafal Tomecki, Krzysztof Goryca, Malgorzata Rydzanicz, Mateusz Chmielarczyk, Malgorzata Szostakowska-Rodzos, Marta Wisniewska, Filip Lyczek, Aleksandra Helwak, David Tollervey, Grzegorz Kudla, Ewa A Grzybowska

Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance

Abl激酶突变导致药物结合动力学改变,提示了一种新的伊马替尼耐药机制。

Lyczek, Agatha; Berger, Benedict-Tilman; Rangwala, Aziz M; Paung, YiTing; Tom, Jessica; Philipose, Hannah; Guo, Jiaye; Albanese, Steven K; Robers, Matthew B; Knapp, Stefan; Chodera, John D; Seeliger, Markus A

The interactome of multifunctional HAX1 protein suggests its role in the regulation of energy metabolism, de-aggregation, cytoskeleton organization and RNA-processing

多功能 HAX1 蛋白的相互作用组表明其在调节能量代谢、解聚集、细胞骨架组织和 RNA 加工中发挥作用

Maciej Wakula, Anna Balcerak, Tymon Rubel, Mateusz Chmielarczyk, Ryszard Konopinski, Filip Lyczek, Ewa A Grzybowska

Transplanted human glial-restricted progenitors can rescue the survival of dysmyelinated mice independent of the production of mature, compact myelin

移植的人类神经胶质细胞限制性祖细胞可以挽救髓鞘发育不良小鼠的存活,而无需产生成熟的致密髓鞘。

Lyczek, Agatha; Arnold, Antje; Zhang, Jiangyang; Campanelli, James T; Janowski, Miroslaw; Bulte, Jeff W M; Walczak, Piotr

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles

Src特异性肽大环抑制细胞内激酶的结构和生化基础

Aleem, Saadat; Georghiou, George; Kleiner, Ralph E; Guja, Kip; Craddock, Barbara P; Lyczek, Agatha; Chan, Alix I; Garcia-Diaz, Miguel; Miller, W Todd; Liu, David R; Seeliger, Markus A

Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity

FYN SH2结构域内动态耦合的残基是解锁其活性的关键。

Huculeci, Radu; Cilia, Elisa; Lyczek, Agatha; Buts, Lieven; Houben, Klaartje; Seeliger, Markus A; van Nuland, Nico; Lenaerts, Tom

Survival of neural progenitors allografted into the CNS of immunocompetent recipients is highly dependent on transplantation site

移植到免疫功能正常的受体中枢神经系统(CNS)的神经祖细胞的存活高度依赖于移植部位。

Janowski, M; Engels, C; Gorelik, M; Lyczek, A; Bernard, S; Bulte, J W M; Walczak, P

The evaluation of treatment plans in high-dose-rate endobronchial brachytherapy by utilizing 2D and 3D computed tomography imaging methods

利用二维和三维计算机断层扫描成像方法评估高剂量率支气管内近距离放射治疗的治疗计划

Sawicki, Marcin; Kazalski, Damian; Lyczek, Jarosław; Kowalik, Lukasz

Cell size and velocity of injection are major determinants of the safety of intracarotid stem cell transplantation

细胞大小和注射速度是颈动脉内干细胞移植安全性的主要决定因素

Miroslaw Janowski, Agatha Lyczek, Charla Engels, Jiadi Xu, Barbara Lukomska, Jeff W M Bulte, Piotr Walczak