文献库，生知库 | 链接生命科学的每一步

Heather J Faust ，Margaret H Chang ，A Helena Jonsson ，Erin Theisen ，Nelson M LaMarche ，William V Trim ，Lydia Lynch ，Peter A Nigrovic ，Michael B Brenner

免疫/内分泌

细胞生物学

关节炎

Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis

脂肪细胞相关的糖皮质激素信号传导调节正常的成纤维细胞功能，而这种功能在炎症性关节炎中丧失。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-52586-x

Heather J Faust ，Tan-Yun Cheng ，Ilya Korsunsky ，Gerald F M Watts ，Shani T Gal-Oz ，William V Trim ，Suppawat Kongthong ，Anna Helena Jonsson ，Daimon P Simmons ，Fan Zhang ，Robert Padera ，Susan Chubinskaya ，Soumya Raychaudhuri ，Lydia Lynch ，D Branch Moody ，Michael B Brenner

Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation

UCP1 的半胱氨酸 253 调节能量消耗和性别依赖性脂肪组织炎症

期刊:Cell Metabolism

影响因子:27.7

doi:10.1016/j.cmet.2021.11.003

Evanna L Mills ，Cathal Harmon ，Mark P Jedrychowski ，Haopeng Xiao ，Anja V Gruszczyk ，Gary A Bradshaw ，Nhien Tran ，Ryan Garrity ，Dina Laznik-Bogoslavski ，John Szpyt ，Hannah Prendeville ，Lydia Lynch ，Michael P Murphy ，Steven P Gygi ，Bruce M Spiegelman ，Edward T Chouchani

Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function

肥胖肿瘤微环境对CD8 T细胞浸润和效应功能的抑制作用

期刊:Journal of Experimental Medicine

影响因子:12.6

doi:10.1084/jem.20210042

Lydia Dyck ，Hannah Prendeville ，Mathilde Raverdeau ，Mieszko M Wilk ，Roisin M Loftus ，Aaron Douglas ，Janet McCormack ，Bruce Moran ，Michael Wilkinson ，Evanna L Mills ，Michael Doughty ，Aurelie Fabre ，Helen Heneghan ，Carel LeRoux ，Andrew Hogan ，Edward T Chouchani ，Donal O'Shea ，Donal Brennan ，Lydia Lynch

Human Hepatic CD56bright NK Cells Display a Tissue-Resident Transcriptional Profile and Enhanced Ability to Kill Allogenic CD8+ T Cells

人类肝脏 CD56bright NK 细胞表现出组织驻留转录谱和增强的杀死同种异体 CD8+ T 细胞的能力

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2022.921212

Gráinne Jameson, Cathal Harmon, Rhyla Mae Santiago, Diarmaid D Houlihan, Tom K Gallagher, Lydia Lynch, Mark W Robinson, Cliona O'Farrelly

High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue

高脂饮食迅速改变脂肪组织中浆细胞样树突状细胞的运输、表型和功能

期刊:Journal of Immunology

影响因子:3.6

doi:10.4049/jimmunol.2100022

Susanne Stutte, Hellen Ishikawa-Ankerhold, Lydia Lynch, Sarah Eickhoff, Simona Nasiscionyte, Chenglong Guo, Dominic van den Heuvel, Daniel Setzensack, Marco Colonna, Daniela Maier-Begandt, Ludwig Weckbach, Thomas Brocker, Christian Schulz, Barbara Walzog, Ulrich von Andrian0

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

胸腺中建立的独特代谢程序控制着肿瘤微环境中γδ T细胞亚群的效应功能。

期刊:Nature Immunology

影响因子:27.7

doi:10.1038/s41590-020-00848-3

Noella Lopes #,Claire McIntyre #,Stefania Martin #,Mathilde Raverdeau #,Nital Sumaria,Ayano C Kohlgruber,Gina J Fiala,Leandro Z Agudelo,Lydia Dyck,Harry Kane,Aaron Douglas,Stephen Cunningham,Hannah Prendeville,Roisin Loftus,Colleen Carmody,Philippe Pierre,Manolis Kellis,Michael Brenner,Rafael J Argüello,Bruno Silva-Santos #,Daniel J Pennington #,Lydia Lynch #

UCP1 governs liver extracellular succinate and inflammatory pathogenesis

UCP1调控肝脏细胞外琥珀酸和炎症发病机制

期刊:Nature Metabolism

影响因子:18.9

doi:10.1038/s42255-021-00389-5

Evanna L Mills ，Cathal Harmon ，Mark P Jedrychowski ，Haopeng Xiao ，Ryan Garrity ，Nhien V Tran ，Gary A Bradshaw ，Accalia Fu ，John Szpyt ，Anita Reddy ，Hannah Prendeville ，Nika N Danial ，Steven P Gygi ，Lydia Lynch ，Edward T Chouchani

Type II NKT Cell Agonist, Sulfatide, Is an Effective Adjuvant for Oral Heat-Killed Cholera Vaccines

II 型 NKT 细胞激动剂硫脂是口服热灭活霍乱疫苗的有效佐剂

期刊:Vaccines

影响因子:

doi:10.3390/vaccines9060619

Aqel Albutti, Stephanie Longet, Craig P McEntee, Shauna Quinn, Alex Liddicoat, Cristiana Rîmniceanu, Nils Lycke, Lydia Lynch, Susanna Cardell, Ed C Lavelle

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis

不同的iNKT细胞群利用IFNγ或内质网应激诱导的IL-10来控制脂肪组织稳态

期刊:Cell Metabolism

影响因子:27.7

doi:10.1016/j.cmet.2020.05.017

Nelson M LaMarche ，Harry Kane ，Ayano C Kohlgruber ，Han Dong ，Lydia Lynch ，Michael B Brenner

Adipose tissue harbors pathogenic T cells in obesity that exacerbate inflammatory arthritis

肥胖症患者的脂肪组织中含有致病性T细胞，这些细胞会加剧炎症性关节炎。

Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis

脂肪细胞相关的糖皮质激素信号传导调节正常的成纤维细胞功能，而这种功能在炎症性关节炎中丧失。

Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation

UCP1 的半胱氨酸 253 调节能量消耗和性别依赖性脂肪组织炎症

Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function

肥胖肿瘤微环境对CD8 T细胞浸润和效应功能的抑制作用

Human Hepatic CD56bright NK Cells Display a Tissue-Resident Transcriptional Profile and Enhanced Ability to Kill Allogenic CD8+ T Cells

人类肝脏 CD56bright NK 细胞表现出组织驻留转录谱和增强的杀死同种异体 CD8+ T 细胞的能力

High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue

高脂饮食迅速改变脂肪组织中浆细胞样树突状细胞的运输、表型和功能

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

胸腺中建立的独特代谢程序控制着肿瘤微环境中γδ T细胞亚群的效应功能。

UCP1 governs liver extracellular succinate and inflammatory pathogenesis

UCP1调控肝脏细胞外琥珀酸和炎症发病机制

Type II NKT Cell Agonist, Sulfatide, Is an Effective Adjuvant for Oral Heat-Killed Cholera Vaccines

II 型 NKT 细胞激动剂硫脂是口服热灭活霍乱疫苗的有效佐剂

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis

不同的iNKT细胞群利用IFNγ或内质网应激诱导的IL-10来控制脂肪组织稳态