日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

主能量稳态调节器 PGC-1α 具有 mRNA 核输出功能

Simeon R Mihaylov #, Lydia M Castelli #, Ya-Hui Lin #, Aytac Gül, Nikita Soni, Christopher Hastings, Helen R Flynn, Oana Păun, Mark J Dickman, Ambrosius P Snijders, Robert Goldstone, Oliver Bandmann, Tatyana A Shelkovnikova, Heather Mortiboys, Sila K Ultanir, Guillaume M Hautbergue

A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations

Y374X TDP43 截断导致肌萎缩侧索硬化成纤维细胞的代谢特征发生改变,这是由丙酮酸和 TCA 循环中间体改变引起的

Scott P Allen, Afnan Al Sultan, Elaine Kabucho Kibirige, Erin Tonkiss, Keaton J Hamer, Lydia M Castelli, Ya-Hui Lin, Sarah Roscoe, Nikolaos Stefanidis, Richard J Mead, J Robin Highley, Johnathan Cooper-Knock, Guillaume M Hautbergue, Paul R Heath, Janine Kirby, Pamela J Shaw

Translation factor and RNA binding protein mRNA interactomes support broader RNA regulons for posttranscriptional control

翻译因子和 RNA 结合蛋白 mRNA 相互作用组支持更广泛的 RNA 调控子进行转录后控制

Christopher J Kershaw, Michael G Nelson, Lydia M Castelli, Martin D Jennings, Jennifer Lui, David Talavera, Chris M Grant, Graham D Pavitt, Simon J Hubbard, Mark P Ashe

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation

TMEM106B 的缺失会破坏自噬体成熟,从而加剧 C9ALS/FTD DPR 病理

Claudia S Bauer, Christopher P Webster, Allan C Shaw, Jannigje R Kok, Lydia M Castelli, Ya-Hui Lin, Emma F Smith, Francisco Illanes-Álvarez, Adrian Higginbottom, Pamela J Shaw, Mimoun Azzouz, Laura Ferraiuolo, Guillaume M Hautbergue, Andrew J Grierson, Kurt J De Vos

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

SRSF1依赖性抑制C9ORF72重复RNA核输出:肌萎缩侧索硬化症神经保护的全基因组机制

Lydia M Castelli # ,Luisa Cutillo # ,Cleide Dos Santos Souza ,Alvaro Sanchez-Martinez ,Ilaria Granata ,Ya-Hui Lin ,Monika A Myszczynska ,Paul R Heath ,Matthew R Livesey ,Ke Ning ,Mimoun Azzouz ,Pamela J Shaw ,Mario R Guarracino ,Alexander J Whitworth ,Laura Ferraiuolo ,Marta Milo ,Guillaume M Hautbergue

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease

直接转化的星形胶质细胞保留了供体成纤维细胞的衰老特征,并阐明了星形胶质细胞对人类中枢神经系统健康和疾病的贡献

Noemi Gatto, Cleide Dos Santos Souza, Allan C Shaw, Simon M Bell, Monika A Myszczynska, Samantha Powers, Kathrin Meyer, Lydia M Castelli, Evangelia Karyka, Heather Mortiboys, Mimoun Azzouz, Guillaume M Hautbergue, Nóra M Márkus, Pamela J Shaw, Laura Ferraiuolo

Overlapping regions of Caf20 mediate its interactions with the mRNA-5'cap-binding protein eIF4E and with ribosomes

Caf20 的重叠区域介导其与 mRNA-5' 帽结合蛋白 eIF4E 以及核糖体的相互作用

Ebelechukwu C Nwokoye, Eiman AlNaseem, Robert A Crawford, Lydia M Castelli, Martin D Jennings, Christopher J Kershaw, Graham D Pavitt

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis

星形胶质细胞腺苷脱氨酶损失增加肌萎缩侧索硬化症中的运动神经元毒性

Scott P Allen, Benjamin Hall, Lydia M Castelli, Laura Francis, Ryan Woof, Alexandros P Siskos, Eirini Kouloura, Elizabeth Gray, Alexander G Thompson, Kevin Talbot, Adrian Higginbottom, Monika Myszczynska, Chloe F Allen, Matthew J Stopford, Jordan Hemingway, Claudia S Bauer, Christopher P Webster, Ku

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

通过星形胶质细胞衍生的细胞外囊泡分泌的微小 RNA 导致 C9orf72 ALS 中的神经网络退化

André Varcianna, Monika A Myszczynska, Lydia M Castelli, Brendan O'Neill, Yeseul Kim, Jordan Talbot, Sophie Nyberg, Immanuelle Nyamali, Paul R Heath, Matthew J Stopford, Guillaume M Hautbergue, Laura Ferraiuolo

Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

稳定的转基因 C9orf72 斑马鱼模拟了 ALS/FTD 表型的关键方面并揭示了新的病理特征

Matthew P Shaw, Adrian Higginbottom, Alexander McGown, Lydia M Castelli, Evlyn James, Guillaume M Hautbergue, Pamela J Shaw, Tennore M Ramesh