日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An ELISA for discovering protein-protein interaction inhibitors: Blocking lysinoalanine crosslinking between subunits of the spirochete flagellar hook as a test case

一种用于发现蛋白质-蛋白质相互作用抑制剂的ELISA方法:以阻断螺旋体鞭毛钩亚基间的赖氨酸丙氨酸交联为例

Deshpande, Maithili; Lynch, Michael J; Kurniyati, Kurni; Li, Chunhao; Crane, Brian R

A MinD-like ATPase couples flagellation and cell division in spirochetes

螺旋体中一种类似MinD的ATPase将鞭毛运动和细胞分裂偶联起来

Zhang, Kai; Guo, Wangbiao; Lynch, Michael J; Crane, Brian R; Liu, Jun; Li, Chunhao

Notes from the Field: Severe Medetomidine Withdrawal Syndrome in Patients Using Illegally Manufactured Opioids - Pittsburgh, Pennsylvania, October 2024-March 2025

现场报告:使用非法制造的阿片类药物的患者出现严重的美托咪定戒断综合征——宾夕法尼亚州匹兹堡,2024年10月至2025年3月

Ostrowski, Simon J; Tamama, Kenichi; Trautman, William J; Stratton, Darien L; Lynch, Michael J

Lactate dehydrogenase is the Achilles' heel of Lyme disease bacterium Borreliella burgdorferi.

乳酸脱氢酶是莱姆病细菌伯氏疏螺旋体的阿喀琉斯之踵

Sze Ching Wooen, Lynch Michael J, Zhang Kai, Neau David B, Ealick Steven E, Crane Brian R, Li Chunhao

Inhibitors of Lysinoalanine Cross-Linking in the Flagella Hook as Antimicrobials against Spirochetes

鞭毛钩中赖氨酸丙氨酸交联抑制剂作为抗螺旋体抗菌剂

Lynch, Michael J; Kurniyati, Kurni; Deshpande, Maithili; Charon, Nyles W; Li, Chunhao; Crane, Brian R

The Flagellin-Specific Chaperone FliS of Borrelia burgdorferi Controls the Cytoplasmic Pool of Flagellins at the Level of Translation Initiation, Secretion, and Proteolysis

伯氏疏螺旋体鞭毛蛋白特异性分子伴侣FliS在翻译起始、分泌和蛋白水解水平上调控细胞质鞭毛蛋白库。

Sze, Ching Wooen; Zhang, Kai; Lynch, Michael J; Guo, Wangbiao; Liu, Jun; Crane, Brian R; Li, Chunhao

Lactate dehydrogenase is the Achilles' heel of Lyme disease bacterium Borreliella burgdorferi

乳酸脱氢酶是莱姆病病原体伯氏疏螺旋体的阿喀琉斯之踵。

Sze, Ching Wooen; Lynch, Michael J; Zhang, Kai; Neau, David B; Ealick, Steven E; Crane, Brian R; Li, Chunhao

A telemedicine bridge clinic improves access and reduces cost for opioid use disorder care

远程医疗桥梁诊所能够改善阿片类药物使用障碍患者的就医途径并降低治疗成本。

Lynch, Michael J; Vargas, Dominic; Winger, Mary E; Kanter, Justin; Meyers, Jessica; Schuster, James; Yealy, Donald M

MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi

MCP5是一种甲基受体趋化蛋白,受Hk1-Rrp1和Rrp2-RpoN-RpoS通路调控,是伯氏疏螺旋体逃避免疫所必需的。

Raghunandanan, Sajith; Zhang, Kai; Zhang, Yan; Sze, Ching Wooen; Priya, Raj; Luo, Yongliang; Lynch, Michael J; Crane, Brian R; Li, Chunhao; Yang, X Frank

A chemosensory-like histidine kinase is dispensable for chemotaxis in vitro but regulates the virulence of Borrelia burgdorferi through modulating the stability of RpoS

一种类似化学感受器的组氨酸激酶在体外趋化作用中并非必需,但它通过调节RpoS的稳定性来调控伯氏疏螺旋体的毒力。

Sze, Ching Wooen; Zhang, Kai; Lynch, Michael J; Iyer, Radha; Crane, Brian R; Schwartz, Ira; Li, Chunhao