日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of Nanoparticle Properties for Optimal Drug Delivery across a Physiological Cell Barrier

鉴定纳米粒子特性以实现跨生理细胞屏障的最佳药物输送

Aisling M Ross, Rachel M Cahalane, Darragh R Walsh, Andreas M Grabrucker, Lynnette Marcar, John J E Mulvihill

The effect of serum starvation on tight junctional proteins and barrier formation in Caco-2 cells

血清饥饿对 Caco-2 细胞紧密连接蛋白和屏障形成的影响

Aisling M Ross, Darragh R Walsh, Rachel M Cahalane, Lynnette Marcar, John J E Mulvihill

Frequent traces of EBV infection in Hodgkin and non-Hodgkin lymphomas classified as EBV-negative by routine methods: expanding the landscape of EBV-related lymphomas

常规方法分类为 EBV 阴性的霍奇金淋巴瘤和非霍奇金淋巴瘤中经常出现 EBV 感染痕迹:扩大 EBV 相关淋巴瘤的范围

Lucia Mundo, Leonardo Del Porro, Massimo Granai, Maria Chiara Siciliano, Virginia Mancini, Raffaella Santi, Lynnette Marcar, Katerina Vrzalikova, Federica Vergoni, Gioia Di Stefano, Gianluca Schiavoni, Giovanna Segreto, Noel Onyango, Joshua Akelo Nyagol, Teresa Amato, Cristiana Bellan, Ioannis Anagn

Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity

EGFR突变型肺癌对酪氨酸激酶抑制剂治疗的获得性耐药促进PARP抑制剂的敏感性

Lynnette Marcar ,Kankana Bardhan ,Liliana Gheorghiu ,Patrick Dinkelborg ,Heike Pfäffle ,Qi Liu ,Meng Wang ,Zofia Piotrowska ,Lecia V Sequist ,Kerstin Borgmann ,Jeffrey E Settleman ,Jeffrey A Engelman ,Aaron N Hata ,Henning Willers

PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53

无论是否使用电离辐射,PARP-1 抑制都会优先对具有突变 TP53 的癌细胞产生活性氧介导的细胞毒性

Qi Liu, Liliana Gheorghiu, Michael Drumm, Rebecca Clayman, Alec Eidelman, Matthew F Wszolek, Aria Olumi, Adam Feldman, Meng Wang, Lynnette Marcar, Deborah E Citrin, Chin-Lee Wu, Cyril H Benes, Jason A Efstathiou, Henning Willers

Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway

骨桥蛋白-EGFR通路介导的干细胞样特性使KRAS突变肺癌具有放射抗性

Meng Wang, Jing Han, Lynnette Marcar, Josh Black, Qi Liu, Xiangyong Li, Kshithija Nagulapalli, Lecia V Sequist, Raymond H Mak, Cyril H Benes, Theodore S Hong, Kristin Gurtner, Mechthild Krause, Michael Baumann, Jing X Kang, Johnathan R Whetstine, Henning Willers

MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4

MAGE-A 癌症/睾丸抗原抑制 MDM2 泛素化功能并促进 MDM4 水平升高

Lynnette Marcar, Bianca Ihrig, John Hourihan, Susan E Bray, Philip R Quinlan, Lee B Jordan, Alastair M Thompson, Ted R Hupp, David W Meek

p53-dependent repression of polo-like kinase-1 (PLK1)

p53 依赖的 polo 样激酶 1 (PLK1) 抑制

Lynsey McKenzie, Sharon King, Lynnette Marcar, Sam Nicol, Sylvia S Dias, Katie Schumm, Pamela Robertson, Jean-Christophe Bourdon, Neil Perkins, Frances Fuller-Pace, David W Meek

FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53

FKBP25 是 p53 通路的新型调节剂,可诱导 MDM2 降解和 p53 激活

Anna Maria Ochocka, Petros Kampanis, Samantha Nicol, Nerea Allende-Vega, Miranda Cox, Lynnette Marcar, Diane Milne, Frances Fuller-Pace, David Meek

Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma

致癌蛋白激酶 Pim-1 水平升高会诱导培养细胞中的 p53 通路,并与套细胞淋巴瘤中的 Mdm2 增加相关

Carol Hogan, Caroline Hutchison, Lynnette Marcar, Diane Milne, Mark Saville, John Goodlad, Neil Kernohan, David Meek