The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect
p53错义变异体R248Q的半衰期延长,促进其积累并与野生型p53形成异源四聚体,从而发挥显性负效应。
期刊:Cancer Research
影响因子:12.5
doi:10.1158/0008-5472.CAN-24-1136
Nancy Klemm,Roman R Schimmer,Nils K Konrad,Flavian Thelen,Jonas Fullin,Ebru Topçu,Christian Koch,Milena Treacy,Matthew Joseph Leventhal,Marco M Bühler,Veronika Lysenko,Alexandre P A Theocharides,Kari J Kurppa,Stefan Balabanov,Tuncay Baubec,Andrei V Krivtsov,Peter G Miller,Scott A Armstrong,Benjamin L Ebert,Markus G Manz,Cesar Nombela-Arrieta,Steffen Boettcher