Integrated transcriptome and cell phenotype analysis suggest involvement of PARP1 cleavage, Hippo/Wnt, TGF-β and MAPK signaling pathways in ovarian cancer cells response to cannabis and PARP1 inhibitor treatment
综合转录组和细胞表型分析表明 PARP1 裂解、Hippo/Wnt、TGF-β 和 MAPK 信号通路参与了卵巢癌细胞对大麻和 PARP1 抑制剂治疗的反应
期刊:Frontiers in Genetics
影响因子:2.8
doi:10.3389/fgene.2024.1333964
Nurit Shalev, Michelle Kendall, Navin Kumar, Sudeep Tiwari, Seegehalli M Anil, Hagit Hauschner, Savvemala G Swamy, Adi Doron-Faingenboim, Eduard Belausov, Bruce E Kendall, Hinanit Koltai
信号转导
肿瘤
卵巢癌
肿瘤细胞
Hippo
MAPK/ERK
TGF-β
Wnt/β-Catenin