日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition

以激酶组为重点的CRISPR-Cas9筛选非洲裔患者来源的乳腺癌类器官,鉴定出关键激酶以及EGFR和FGFR1抑制的协同作用

Florencia P Madorsky Rowdo ,Rachel Martini ,Sarah E Ackermann ,Colin P Tang ,Marvel Tranquille ,Adriana Irizarry ,Ilkay Us ,Omar Alawa ,Jenna E Moyer ,Michael Sigouros ,John Nguyen ,Majd Al Assaad ,Esther Cheng ,Paula S Ginter ,Jyothi Manohar ,Brian Stonaker ,Richard Boateng ,Joseph K Oppong ,Ernest K Adjei ,Baffour Awuah ,Ishmael Kyei ,Francis S Aitpillah ,Michael O Adinku ,Kwasi Ankomah ,Ernest B Osei-Bonsu ,Kofi K Gyan ,Syed Hoda ,Lisa Newman ,Juan Miguel Mosquera ,Andrea Sboner ,Olivier Elemento ,Lukas E Dow ,Melissa B Davis ,M Laura Martin

Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer

铁螯合疗法可诱导转移性卵巢癌的先天免疫控制

Tito A Sandoval ,Camilla Salvagno ,Chang-Suk Chae ,Deepika Awasthi ,Paolo Giovanelli ,Matias Marin Falco ,Sung-Min Hwang ,Eli Teran-Cabanillas ,Lasse Suominen ,Takahiro Yamazaki ,Hui-Hsuan Kuo ,Jenna E Moyer ,M Laura Martin ,Jyothi Manohar ,Kihwan Kim ,Maria A Sierra ,Yusibeska Ramos ,Chen Tan ,Alexander Emmanuelli ,Minkyung Song ,Diana K Morales ,Dmitriy Zamarin ,Melissa K Frey ,Evelyn Cantillo ,Eloise Chapman-Davis ,Kevin Holcomb ,Christopher E Mason ,Lorenzo Galluzzi ,Zhen Ni Zhou ,Anna Vähärautio ,Suzanne M Cloonan ,Juan R Cubillos-Ruiz

Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve immunotherapy

代谢调节因子PKM2的缺乏会激活磷酸戊糖途径,并生成TCF1+祖细胞CD8+ T细胞,从而改善免疫治疗效果。

Geoffrey J Markowitz ,Yi Ban # ,Diamile A Tavarez # ,Liron Yoffe # ,Enrique Podaza # ,Yongfeng He ,Mitchell T Martin ,Michael J P Crowley ,Tito A Sandoval ,Dingcheng Gao ,M Laura Martin ,Olivier Elemento ,Juan R Cubillos-Ruiz ,Timothy E McGraw ,Nasser K Altorki ,Vivek Mittal

A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS

胰腺癌类器官平台鉴定出一种针对突变型KRAS的特异性抑制剂

Xiaohua Duan ,Tuo Zhang ,Lingling Feng ,Neranjan de Silva ,Benjamin Greenspun ,Xing Wang ,Jenna Moyer ,M Laura Martin ,Rohit Chandwani ,Olivier Elemento ,Steven D Leach ,Todd Evans ,Shuibing Chen ,Fong Cheng Pan

Gut bacteria-derived serotonin promotes immune tolerance in early life

肠道细菌产生的血清素促进生命早期的免疫耐受

Katherine Z Sanidad, Stephanie L Rager, Hannah C Carrow, Aparna Ananthanarayanan, Ryann Callaghan, Lucy R Hart, Tingting Li, Purnima Ravisankar, Julia A Brown, Mohammed Amir, Jenny C Jin, Alexandria Rose Savage, Ryan Luo, Florencia Mardorsky Rowdo, M Laura Martin, Randi B Silver, Chun-Jun Guo, Jan K

Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade

代谢调节剂 PKM2 的缺乏会激活戊糖磷酸途径并产生 TCF1+ 祖细胞 CD8+ T 细胞以改善检查点阻断

Geoffrey J Markowitz, Yi Ban, Diamile A Tavarez, Liron Yoffe, Enrique Podaza, Yongfeng He, Mitchell T Martin, Michael J P Crowley, Tito A Sandoval, Dingcheng Gao, M Laura Martin, Olivier Elemento, Juan R Cubillos-Ruiz, Timothy E McGraw, Nasser K Altorki, Vivek Mittal

Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infection

肠道菌群衍生的代谢产物可预防SARS-CoV-2感染

Julia A Brown ,Katherine Z Sanidad ,Serena Lucotti ,Carolin M Lieber ,Robert M Cox ,Aparna Ananthanarayanan ,Srijani Basu ,Justin Chen ,Mengrou Shan ,Mohammed Amir ,Fabian Schmidt ,Yiska Weisblum ,Michele Cioffi ,Tingting Li ,Florencia Madorsky Rowdo ,M Laura Martin ,Chun-Jun Guo ,Costas Lyssiotis ,Brian T Layden ,Andrew J Dannenberg ,Paul D Bieniasz ,Benhur Lee ,Naohiro Inohara ,Irina Matei ,Richard K Plemper ,Melody Y Zeng

The regulation of CD73 in non-small cell lung cancer

CD73在非小细胞肺癌中的调控

Yumin Han, Trevor Lee, Yongfeng He, Renuka Raman, Adriana Irizarry, M Laura Martin, Giuseppe Giaccone

The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62

乳酸-NAD+轴通过下调p62激活癌症相关成纤维细胞

Juan F Linares, Tania Cid-Diaz, Angeles Duran, Marta Osrodek, Anxo Martinez-Ordoñez, Miguel Reina-Campos, Hui-Hsuan Kuo, Olivier Elemento, M Laura Martin, Thekla Cordes, Timothy C Thompson, Christian M Metallo, Jorge Moscat, Maria T Diaz-Meco

Optimized Protocol To Analyze Changes in the Lipidome of Xenografts after Treatment with 2-Hydroxyoleic Acid

优化方案分析异种移植瘤经 2-羟基油酸处理后脂质组的变化

Roberto Fernández, Jone Garate, Sergio Lage, Silvia Terés, Mónica Higuera, Joan Bestard-Escalas, M Laura Martin, Daniel H López, Francisca Guardiola-Serrano, Pablo V Escribá, Gwendolyn Barceló-Coblijn, José A Fernández