日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Declining research interest among oncology residents: insights into the academic career from a nationwide longitudinal study in France

法国一项全国性纵向研究揭示肿瘤科住院医师科研兴趣下降:对学术生涯的启示

Taranto, N; Duval, M; Raynaud, C; Boilève, A; Naoun, N; Rousseau, A; Ashton, E; Ollivier, L; Alexandre, J; Huguet, F; Kfoury, M; Delaye, M; Hilmi, M

Systematic comparison of quantity and quality of RNA recovered with commercial FFPE tissue extraction kits

使用商用 FFPE 组织提取试剂盒回收的 RNA 数量和质量的系统比较

Sukoluhle Dube #, Sharefa Al-Mannai #, Li Liu, Sara Tomei, Satanay Hubrack, Shimaa Sherif, Ayesha Jabeen, Eiman I Ahmed, Apryl Sanchez, William Mifsud, Davide Bedognetti, Wouter Hendrickx, Christophe M Raynaud

MUC2 expression modulates immune infiltration in colorectal cancer

MUC2 表达调节结直肠癌的免疫浸润

Christophe M Raynaud, Ayesha Jabeen, Eiman I Ahmed, Satanay Hubrack, Apryl Sanchez, Shimaa Sherif, Ahmad A Al-Shaibi, Bernice Lo, Jessica Roelands, Davide Bedognetti, Wouter Hendrickx

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones

通过优化三环喹啉酮发现一种用于抑制BCL6的体内化学探针

Harnden, Alice C; Davis, Owen A; Box, Gary M; Hayes, Angela; Johnson, Louise D; Henley, Alan T; de Haven Brandon, Alexis K; Valenti, Melanie; Cheung, Kwai-Ming J; Brennan, Alfie; Huckvale, Rosemary; Pierrat, Olivier A; Talbot, Rachel; Bright, Michael D; Akpinar, Hafize Aysin; Miller, Daniel S J; Tarantino, Dalia; Gowan, Sharon; de Klerk, Selby; McAndrew, Peter Craig; Le Bihan, Yann-Vaï; Meniconi, Mirco; Burke, Rosemary; Kirkin, Vladimir; van Montfort, Rob L M; Raynaud, Florence I; Rossanese, Olivia W; Bellenie, Benjamin R; Hoelder, Swen

Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors

优化形状互补性有助于发现高效的三环BCL6抑制剂

Davis, Owen A; Cheung, Kwai-Ming J; Brennan, Alfie; Lloyd, Matthew G; Rodrigues, Matthew J; Pierrat, Olivier A; Collie, Gavin W; Le Bihan, Yann-Vaï; Huckvale, Rosemary; Harnden, Alice C; Varela, Ana; Bright, Michael D; Eve, Paul; Hayes, Angela; Henley, Alan T; Carter, Michael D; McAndrew, P Craig; Talbot, Rachel; Burke, Rosemary; van Montfort, Rob L M; Raynaud, Florence I; Rossanese, Olivia W; Meniconi, Mirco; Bellenie, Benjamin R; Hoelder, Swen

Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo

提高结合亲和力和药代动力学可实现体内BCL6的持续降解

Huckvale, Rosemary; Harnden, Alice C; Cheung, Kwai-Ming J; Pierrat, Olivier A; Talbot, Rachel; Box, Gary M; Henley, Alan T; de Haven Brandon, Alexis K; Hallsworth, Albert E; Bright, Michael D; Akpinar, Hafize Aysin; Miller, Daniel S J; Tarantino, Dalia; Gowan, Sharon; Hayes, Angela; Gunnell, Emma A; Brennan, Alfie; Davis, Owen A; Johnson, Louise D; de Klerk, Selby; McAndrew, Craig; Le Bihan, Yann-Vaï; Meniconi, Mirco; Burke, Rosemary; Kirkin, Vladimir; van Montfort, Rob L M; Raynaud, Florence I; Rossanese, Olivia W; Bellenie, Benjamin R; Hoelder, Swen

De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females

X染色体连锁基因CLCN4的新生突变和遗传突变与男性和女性的综合征性智力障碍、行为障碍和癫痫发作有关。

Palmer, E E; Stuhlmann, T; Weinert, S; Haan, E; Van Esch, H; Holvoet, M; Boyle, J; Leffler, M; Raynaud, M; Moraine, C; van Bokhoven, H; Kleefstra, T; Kahrizi, K; Najmabadi, H; Ropers, H-H; Delgado, M R; Sirsi, D; Golla, S; Sommer, A; Pietryga, M P; Chung, W K; Wynn, J; Rohena, L; Bernardo, E; Hamlin, D; Faux, B M; Grange, D K; Manwaring, L; Tolmie, J; Joss, S; Cobben, J M; Duijkers, F A M; Goehringer, J M; Challman, T D; Hennig, F; Fischer, U; Grimme, A; Suckow, V; Musante, L; Nicholl, J; Shaw, M; Lodh, S P; Niu, Z; Rosenfeld, J A; Stankiewicz, P; Jentsch, T J; Gecz, J; Field, M; Kalscheuer, V M

Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N(2)-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N(8)-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722)

引入甲基可抑制吡啶并[3,4-d]嘧啶单极纺锤体1 (MPS1) 抑制剂的代谢,并促成了 1 期临床候选药物 N(2)-(2-乙氧基-4-(4-甲基-4H-1,2,4-三唑-3-基)苯基)-6-甲基-N(8)-新戊基吡啶并[3,4-d]嘧啶-2,8-二胺 (BOS172722) 的发现。

Woodward, Hannah L; Innocenti, Paolo; Cheung, Kwai-Ming J; Hayes, Angela; Roberts, Jennie; Henley, Alan T; Faisal, Amir; Mak, Grace Wing-Yan; Box, Gary; Westwood, Isaac M; Cronin, Nora; Carter, Michael; Valenti, Melanie; De Haven Brandon, Alexis; O'Fee, Lisa; Saville, Harry; Schmitt, Jessica; Burke, Rosemary; Broccatelli, Fabio; van Montfort, Rob L M; Raynaud, Florence I; Eccles, Suzanne A; Linardopoulos, Spiros; Blagg, Julian; Hoelder, Swen

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes

对 405 个未解析家族的 X 外显子组测序确定了七个新的智力障碍基因

H Hu, S A Haas, J Chelly, H Van Esch, M Raynaud, A P M de Brouwer, S Weinert, G Froyen, S G M Frints, F Laumonnier, T Zemojtel, M I Love, H Richard, A-K Emde, M Bienek, C Jensen, M Hambrock, U Fischer, C Langnick, M Feldkamp, W Wissink-Lindhout, N Lebrun, L Castelnau, J Rucci, R Montjean, O Dorseuil

Validation of the Mini Nutritional Assessment-Short Form in a Population of Frail Elders without Disability. Analysis of the Toulouse Frailty Platform Population in 2013

在无残疾的体弱老年人群中验证简易营养评估量表(Mini Nutritional Assessment-Short Form)的有效性。2013年图卢兹衰弱平台人群分析

Lilamand, M; Kelaiditi, E; Cesari, M; Raynaud-Simon, A; Ghisolfi, A; Guyonnet, S; Vellas, B; van Kan, G Abellan