日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protein buffering of aneuploidy is driven by coordinated factors identified through machine learning

非整倍体的蛋白质缓冲作用是由机器学习识别出的协同因素驱动的。

Heller, Erik Marcel; Barthel, Karen; Räschle, Markus; Schukken, Klaske M; Sheltzer, Jason M; Storchová, Zuzana

Explainable Machine Learning Identifies Factors for Dosage Compensation in Aneuploid Human Cancer Cells

可解释机器学习识别非整倍体人类癌细胞剂量补偿的因素

Heller, Erik Marcel; Barthel, Karen; Räschle, Markus; Schukken, Klaske M; Sheltzer, Jason M; Storchová, Zuzana

Evolving copy number gains promote tumor expansion and bolster mutational diversification

拷贝数增加会促进肿瘤扩张并增强突变多样性

Wang, Zicheng; Xia, Yunong; Mills, Lauren; Nikolakopoulos, Athanasios N; Maeser, Nicole; Dehm, Scott M; Sheltzer, Jason M; Sun, Ruping

An elevated rate of whole-genome duplications in cancers from Black patients

黑人患者癌症的全基因组重复率较高

Leanne M Brown #, Ryan A Hagenson #, Tilen Koklič, Iztok Urbančič, Lu Qiao, Janez Strancar, Jason M Sheltzer

Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor

抑制较低效力靶点可推动临床 p38 抑制剂的抗癌活性

Debanjan Bhattacharjee, Jaweria Bakar, Surbhi P Chitnis, Erin L Sausville, Kumar Dilip Ashtekar, Brianna E Mendelson, Kaitlin Long, Joan C Smith, David E Heppner, Jason M Sheltzer

Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies

染色体不稳定性加速抗癌疗法耐药性的进化

Devon A Lukow, Erin L Sausville, Pavit Suri, Narendra Kumar Chunduri, Angela Wieland, Justin Leu, Joan C Smith, Vishruth Girish, Ankith A Kumar, Jude Kendall, Zihua Wang, Zuzana Storchova, Jason M Sheltzer

Erratum: Correction Notice: A CRISPR Competition Assay to Identify Cancer Genetic Dependencies

勘误:更正声明:一种用于识别癌症遗传依赖性的 CRISPR 竞争性检测方法

Girish, Vishruth; M Sheltzer, Jason

Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer

单染色体扩增在结肠癌中既可作为转移抑制因子,也可作为转移促进因子。

Anand Vasudevan,Prasamit S Baruah,Joan C Smith,Zihua Wang,Nicole M Sayles,Peter Andrews,Jude Kendall,Justin Leu,Narendra Kumar Chunduri,Dan Levy,Michael Wigler,Zuzana Storchová,Jason M Sheltzer

Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract

香烟烟雾暴露和炎症信号传导会增加呼吸道中SARS-CoV-2受体ACE2的表达

Joan C Smith,Erin L Sausville,Vishruth Girish,Monet Lou Yuan,Anand Vasudevan,Kristen M John,Jason M Sheltzer

A CRISPR Competition Assay to Identify Cancer Genetic Dependencies

通过 CRISPR 竞争试验识别癌症遗传依赖性

Vishruth Girish, Jason M Sheltzer