Klotho null mutation leads to retinal degeneration characterized by functional impairment, gliosis, and deposition of amyloid-beta and hyperphosphorylated tau proteins.

Klotho 基因缺失突变导致视网膜变性，其特征是功能障碍、胶质增生以及淀粉样β蛋白和过度磷酸化tau蛋白的沉积