Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
富马酸和琥珀酸在FH和SDH肿瘤抑制基因突变中积累,从而抑制α-KG依赖性组蛋白和DNA去甲基化酶。
期刊:Genes & Development
影响因子:7.7
doi:10.1101/gad.191056.112
Xiao, Mengtao; Yang, Hui; Xu, Wei; Ma, Shenghong; Lin, Huaipeng; Zhu, Honguang; Liu, Lixia; Liu, Ying; Yang, Chen; Xu, Yanhui; Zhao, Shimin; Ye, Dan; Xiong, Yue; Guan, Kun-Liang