文献库，生知库 | 链接生命科学的每一步

Biosynthesis of Antituberculosis Antibiotic Capreomycin Involves a trans-Iterative Adenylation Domain within the Nonribosomal Peptide Synthetase Machinery

抗结核抗生素卷曲霉素的生物合成涉及非核糖体肽合成酶机制中的一个反式迭代腺苷酸化结构域。

doi:10.1021/acs.orglett.5c03112

Lai, Yi-Ting; Peng, Chun-Yu; Liao, Hsiao-Tzu; Hsiao, Po-Yun; Hsieh, Chang-Ko; Luo, Yu-Ru; Huang, Sheng-Cih; Wang, Yung-Lin; Ma, Thomas; Chen, Ya-Rong; Kuo, You-Min; Lin, Yen-Cheng; Chu, John; Chang, Chin-Yuan

发表日期：2025

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Lipid membrane-camouflaged biomimetic nanoparticle for MicroRNA based therapeutic delivery to intestinal epithelial cells

用于将基于microRNA的治疗药物递送至肠上皮细胞的脂质膜伪装仿生纳米颗粒

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-17382-7

Rawat, Manmeet; Nara, Sharda; Gupta, Yash; Ma, Thomas Y; Parasher, Gulshan

Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads

肌球蛋白结合蛋白 C 调节肌节晶格并稳定肌球蛋白头部的 OFF 状态

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-46957-7

Anthony L Hessel, Nichlas M Engels, Michel N Kuehn, Devin Nissen, Rachel L Sadler, Weikang Ma, Thomas C Irving, Wolfgang A Linke, Samantha P Harris

信号转导

发表日期：2024

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Paeoniflorin protects hepatocytes from APAP-induced damage through launching autophagy via the MAPK/mTOR signaling pathway

芍药苷通过MAPK/mTOR信号通路启动自噬，从而保护肝细胞免受对乙酰氨基酚（APAP）诱导的损伤。

期刊:Cellular & Molecular Biology Letters

影响因子:9.2

doi:10.1186/s11658-024-00631-4.

Xinyu Deng ,Yubing Li ,Yuan Chen ,Qichao Hu ,Wenwen Zhang ,Lisheng Chen ,Xiaohua Lu ,Jinhao Zeng ,Xiao Ma ,Thomas Efferth

Lactobacillus acidophilus inhibits the TNF-α-induced increase in intestinal epithelial tight junction permeability via a TLR-2 and PI3K-dependent inhibition of NF-κB activation

嗜酸乳杆菌通过TLR-2和PI3K依赖性抑制NF-κB活化，从而抑制TNF-α诱导的肠上皮紧密连接通透性增加。

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2024.1348010

Haque, Mohammad; Kaminsky, Lauren; Abdulqadir, Raz; Engers, Jessica; Kovtunov, Evgeny; Rawat, Manmeet; Al-Sadi, Rana; Ma, Thomas Y

Genomic and phenotypic characterization of Mycobacterium tuberculosis' closest-related non-tuberculous mycobacteria

结核分枝杆菌最接近的非结核分枝杆菌的基因组和表型特征

期刊:Microbiology Spectrum

影响因子:3.7

doi:10.1128/spectrum.04126-23

Camille Sous, Wafa Frigui, Alexandre Pawlik, Fadel Sayes, Laurence Ma, Thomas Cokelaer, Roland Brosch

微生物学

发表日期：2024

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Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-α-Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex-Dependent Stimulation of Peroxisome Proliferator-Activated Receptor γ and Suppression of NF-κB p65

双歧杆菌BB1菌株通过Toll样受体2/Toll样受体6受体复合物依赖性地刺激过氧化物酶体增殖物激活受体γ并抑制NF-κB p65，从而抑制肿瘤坏死因子-α诱导的肠上皮紧密连接通透性增加。

期刊:American Journal of Pathology

影响因子:3.6

doi:10.1016/j.ajpath.2024.05.012

Abdulqadir, Raz; Al-Sadi, Rana; Haque, Mohammad; Gupta, Yash; Rawat, Manmeet; Ma, Thomas Y

Chemical structure metagenomics of microbial natural products: surveying nonribosomal peptides and beyond

微生物天然产物的化学结构宏基因组学：非核糖体肽及其他物质的概览

期刊:Beilstein Journal of Organic Chemistry

影响因子:2.1

doi:10.3762/bjoc.20.253

Ma, Thomas; Chu, John

微生物学

发表日期：2024

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The complete genome sequence of probiotic Lactobacillus acidophilus ATCC 9224 isolated from sour milk

从酸奶中分离的益生菌嗜酸乳杆菌 ATCC 9224 的完整基因组序列

期刊:Microbiology Resource Announcements

影响因子:0.6

doi:10.1128/mra.00677-23

Kumar, Anand; Rawat, Manmeet; Kunde, Yuliya A; Davenport, Karen W; Al-Sadi, Rana; Chain, Patrick Sam Guy; Ma, Thomas Y

发表日期：2024

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Mechanistic Studies of the Calcium-Dependent Antibiotics via Cofactor Engineering

通过辅因子工程研究钙依赖性抗生素的机制

Biosynthesis of Antituberculosis Antibiotic Capreomycin Involves a trans-Iterative Adenylation Domain within the Nonribosomal Peptide Synthetase Machinery

抗结核抗生素卷曲霉素的生物合成涉及非核糖体肽合成酶机制中的一个反式迭代腺苷酸化结构域。

Lipid membrane-camouflaged biomimetic nanoparticle for MicroRNA based therapeutic delivery to intestinal epithelial cells

用于将基于microRNA的治疗药物递送至肠上皮细胞的脂质膜伪装仿生纳米颗粒

Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads

肌球蛋白结合蛋白 C 调节肌节晶格并稳定肌球蛋白头部的 OFF 状态

Paeoniflorin protects hepatocytes from APAP-induced damage through launching autophagy via the MAPK/mTOR signaling pathway

芍药苷通过MAPK/mTOR信号通路启动自噬，从而保护肝细胞免受对乙酰氨基酚（APAP）诱导的损伤。

Lactobacillus acidophilus inhibits the TNF-α-induced increase in intestinal epithelial tight junction permeability via a TLR-2 and PI3K-dependent inhibition of NF-κB activation

嗜酸乳杆菌通过TLR-2和PI3K依赖性抑制NF-κB活化，从而抑制TNF-α诱导的肠上皮紧密连接通透性增加。

Genomic and phenotypic characterization of Mycobacterium tuberculosis' closest-related non-tuberculous mycobacteria

结核分枝杆菌最接近的非结核分枝杆菌的基因组和表型特征

双歧杆菌BB1菌株通过Toll样受体2/Toll样受体6受体复合物依赖性地刺激过氧化物酶体增殖物激活受体γ并抑制NF-κB p65，从而抑制肿瘤坏死因子-α诱导的肠上皮紧密连接通透性增加。

Chemical structure metagenomics of microbial natural products: surveying nonribosomal peptides and beyond

微生物天然产物的化学结构宏基因组学：非核糖体肽及其他物质的概览

The complete genome sequence of probiotic Lactobacillus acidophilus ATCC 9224 isolated from sour milk

从酸奶中分离的益生菌嗜酸乳杆菌 ATCC 9224 的完整基因组序列