The mitochondrial translocation of phosphorylated EZH2 promotes PARP inhibitor resistance in BRCA1-deficient epithelial ovarian cancer
磷酸化EZH2向线粒体的转位促进BRCA1缺陷型上皮性卵巢癌对PARP抑制剂的耐药性
期刊:Cell Discovery
影响因子:12.5
doi:10.1038/s41421-026-00880-x
Hu, Ling; Ma, Xiaolu; Cai, Xushan; Yan, Tianqing; Zhou, Kaixia; Shan, Chen; Guo, Ning; Zheng, Hui; Wang, Yanchun; Tong, Ying; Xie, Suhong; Zhang, Heng; Chen, Cuncun; Gong, Zhiyun; Guo, Lin; Lu, Renquan
肿瘤
肿瘤免疫
信号转导
卵巢癌
BRCA1
线粒体
EZH2
PARP
磷酸化
