日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase 1 dose escalation study of seribantumab (MM-121), an anti-HER3 monoclonal antibody, in patients with advanced solid tumors

塞里班妥单抗(MM-121,一种抗HER3单克隆抗体)治疗晚期实体瘤患者的1期剂量递增研究

Denlinger, Crystal S; Keedy, Vicki L; Moyo, Victor; MacBeath, Gavin; Shapiro, Geoffrey I

Predicting ligand-dependent tumors from multi-dimensional signaling features.

基于多维信号特征预测配体依赖性肿瘤

Hass Helge, Masson Kristina, Wohlgemuth Sibylle, Paragas Violette, Allen John E, Sevecka Mark, Pace Emily, Timmer Jens, Stelling Joerg, MacBeath Gavin, Schoeberl Birgit, Raue Andreas

Randomized Phase II Trial of Seribantumab in Combination With Paclitaxel in Patients With Advanced Platinum-Resistant or -Refractory Ovarian Cancer

塞利班妥单抗联合紫杉醇治疗铂类耐药或难治性晚期卵巢癌患者的随机II期临床试验

Liu, Joyce F; Ray-Coquard, Isabelle; Selle, Frederic; Poveda, Andrés M; Cibula, David; Hirte, Hal; Hilpert, Felix; Raspagliesi, Francesco; Gladieff, Laurence; Harter, Philipp; Siena, Salvatore; Del Campo, Josep Maria; Tabah-Fisch, Isabelle; Pearlberg, Joseph; Moyo, Victor; Riahi, Kaveh; Nering, Rachel; Kubasek, William; Adiwijaya, Bambang; Czibere, Akos; Naumann, R Wendel; Coleman, Robert L; Vergote, Ignace; MacBeath, Gavin; Pujade-Lauraine, Eric

A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks

多尺度统计力学框架整合了生物物理和基因组数据,用于构建癌症网络。

AlQuraishi, Mohammed; Koytiger, Grigoriy; Jenney, Anne; MacBeath, Gavin; Sorger, Peter K

Suppression of host p53 is critical for Plasmodium liver-stage infection

抑制宿主p53对于疟原虫肝期感染至关重要。

Kaushansky, Alexis; Ye, Albert S; Austin, Laura S; Mikolajczak, Sebastian A; Vaughan, Ashley M; Camargo, Nelly; Metzger, Peter G; Douglass, Alyse N; MacBeath, Gavin; Kappe, Stefan H I

Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks

根据推测的信号转导网络,受体酪氨酸激酶可分为不同的类别。

Wagner, Joel P; Wolf-Yadlin, Alejandro; Sevecka, Mark; Grenier, Jennifer K; Root, David E; Lauffenburger, Douglas A; MacBeath, Gavin

Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected

驱动肿瘤发生的磷酸酪氨酸信号蛋白往往高度相互关联。

Koytiger, Grigoriy; Kaushansky, Alexis; Gordus, Andrew; Rush, John; Sorger, Peter K; MacBeath, Gavin

Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks

抗癌药物的序贯应用可通过重塑细胞凋亡信号网络来增强细胞死亡。

Lee, Michael J; Ye, Albert S; Gardino, Alexandra K; Heijink, Anne Margriet; Sorger, Peter K; MacBeath, Gavin; Yaffe, Michael B

Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements.

酪氨酸磷酸化的 caveolin-1 通过诱导 Vav2-RhoA 介导的细胞骨架重排来阻止细菌的摄取

Boettcher Jan Peter, Kirchner Marieluise, Churin Yuri, Kaushansky Alexis, Pompaiah Malvika, Thorn Hans, Brinkmann Volker, Macbeath Gavin, Meyer Thomas F

Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1

Tarp通过与人类衔接蛋白SHC1的相互作用来调节衣原体诱导的早期宿主细胞存活。

Mehlitz, Adrian; Banhart, Sebastian; Mäurer, André P; Kaushansky, Alexis; Gordus, Andrew G; Zielecki, Julia; Macbeath, Gavin; Meyer, Thomas F