日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery

利用细胞色素P450人源化小鼠模型改进血吸虫病药物研发

Davey, Sarah D; Forde-Thomas, Josephine E; Hulme, Benjamin J; Lees, Kristin; Costain, Alice H; Evans, Mary; Rinaldi, Gabriel; Frame, Laura; Stojanovski, Laste; Simeons, Frederick R C; Tavendale, Amy; MacLeod, A Kenneth; Pichon, Remi; Lee, Yi-Hsuan; Polak, Oktawia; Chalmers, Iain W; Dankwa, Bismark; Odhiambo, Brenda Kisia; Guimaraes, Victor Hugo; Hegarty, Matthew; Swain, Martin T; Aubrey, Wayne; Caldwell, Nicola; MacDonald, Andrew S; Gilbert, Ian H; Baragaña, Beatriz; Read, Kevin D; Hoffmann, Karl F

Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets

全球土壤传播蠕虫的多样性揭示了影响诊断靶点的群体偏向性遗传变异。

Papaiakovou, Marina; Waeschenbach, Andrea; Ajibola, Olumide; Ajjampur, Sitara Sr; Anderson, Roy M; Bailey, Robin; Benjamin-Chung, Jade; Cambra-Pellejà, Maria; Caro, Nicolas R; Chaima, David; Cimino, Rubén O; Cools, Piet; Cossa, Anélsio; Dunn, Julia; Galagan, Sean; Gandasegui, Javier; Grau-Pujol, Berta; Houlder, Emma L; Ibikounlé, Moudachirou; Jenkins, Timothy P; Kalua, Khumbo; Kjetland, Eyrun F; Krolewiecki, Alejandro J; Levecke, Bruno; Luty, Adrian Jf; MacDonald, Andrew S; Mandomando, Inácio; Manuel, Malathi; Martínez-Valladares, Maria; Mejia, Rojelio; Mekonnen, Zeleke; Messa, Augusto Jr; Mpairwe, Harriet; Muchisse, Osvaldo; Muñoz, Jose; Mwinzi, Pauline; Novela, Valdemiro; Odiere, Maurice R; Sacoor, Charfudin; Walson, Judd L; Williams, Steven A; Witek-McManus, Stefan; Littlewood, D Timothy J; Cantacessi, Cinzia; Doyle, Stephen R

The female reproductive tract-gut axis in gastrointestinal parasitic infection

女性生殖道-肠道轴在胃肠道寄生虫感染中的作用

Shorthouse, Olivia; Costain, Alice H; MacDonald, Andrew S; Quintana, Juan F

SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage.

SOX9 在血吸虫病引起的肝损伤中,在肌成纤维细胞驱动的肝肉芽肿完整性和实质修复中起着至关重要的作用

Su Kim, Jokl Elliot, Costain Alice, Simpson Kara, Cheeseman Antonn, Phythian-Adams Alexander, Couper Kevin N, MacDonald Andrew S, Piper Hanley Karen

Dendritic cell dysfunction, including impaired IL-12 production, is associated with chronic pulmonary aspergillosis

树突状细胞功能障碍,包括IL-12产生受损,与慢性肺曲霉病相关。

Colombo, Stefano A P; Gago, Sara; Chamula, Mathilde; Lord, Robert; MacDonald, Andrew S; Kosmidis, Chris

Synergistic blockade of TIGIT and PD-L1 increases type-1 inflammation and improves parasite control during murine blood-stage Plasmodium yoelii non-lethal infection

TIGIT 和 PD-L1 的协同阻断可增强 1 型炎症反应,并改善小鼠血液期约氏疟原虫非致死性感染期间的寄生虫控制。

Dookie, Rebecca S; Villegas-Mendez, Ana; Cheeseman, Antonn; Jones, Adam P; Barroso, Ruben; Barrett, Jordan R; Draper, Simon J; Janse, Chris J; Grogan, Jane L; MacDonald, Andrew S; Couper, Kevin N

Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans.

趋化因子在炎症和疾病期间形成复杂的信号,这些信号可被细胞外基质蛋白聚糖解码

Ridley Amanda J L, Ou Yaqing, Karlsson Richard, Pun Nabina, Birchenough Holly L, Mulholland Iashia Z, Birch Mary L, MacDonald Andrew S, Jowitt Thomas A, Lawless Craig, Miller Rebecca L, Dyer Douglas P

Corrigendum: Dynamics of host immune response development during Schistosoma mansoni infection

更正:曼氏血吸虫感染期间宿主免疫反应发展的动态

Costain, Alice H; Phythian-Adams, Alexander T; Colombo, Stefano A P; Marley, Angela K; Owusu, Christian; Cook, Peter C; Brown, Sheila L; Webb, Lauren M; Lundie, Rachel J; Borger, Jessica G; Smits, Hermelijn H; Berriman, Matthew; MacDonald, Andrew S

Comparative phenotype of circulating versus tissue immune cells in human lung and blood compartments during health and disease

健康和疾病状态下人肺和血液中循环免疫细胞与组织免疫细胞的表型比较

Colombo, Stefano A P; Brown, Sheila L; Hepworth, Matthew R; Hankinson, Jenny; Granato, Felice; Kitchen, Semra J; Hussell, Tracy; Simpson, Angela; Cook, Peter C; MacDonald, Andrew S

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

肺部环境对巨噬细胞发育、激活和功能的影响:逆境中的多样性

Bain, Calum C; MacDonald, Andrew S