日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Discovery of a novel small molecule degrader of wild type and mutant estrogen receptors using DNA encoded libraries

利用DNA编码文库发现一种新型小分子降解剂，可降解野生型和突变型雌激素受体。

期刊:NPJ Breast Cancer
影响因子:7.6
doi:10.1038/s41523-025-00837-5
Devakrishnan, Anil Kumar; Madasu, Chandrashekhar; Wang, Yong; Modukuri, Ramkumar; Bohren, Kurt M; MacKenzie, Kevin R; Young, Damian W; Fuqua, Suzanne A W; Matzuk, Martin M; Palaniappan, Murugesan
信号转导
免疫/内分泌
发表日期：2025
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Metabolism, Pharmacokinetics, and Tissue Distribution of a Selective FK506-Binding Protein 12 F36V Mutant Degrader in Mice

小鼠体内选择性FK506结合蛋白12 F36V突变降解物的代谢、药代动力学和组织分布

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.5c00643
Zhou, Shenzhi; Qin, Xuan; Tran, Kevin; Wang, Jian; Ji, Xingyu; MacKenzie, Kevin R; Chamakuri, Srinivas; Wang, Jin; Li, Feng
代谢
发表日期：2025
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CYP3A Mediates an Unusual C(sp(2))-C(sp(3)) Bond Cleavage via Ipso-Addition of Oxygen in Drug Metabolism

CYP3A通过氧的Ipso加成介导药物代谢中一种不寻常的C(sp(2))-C(sp(3))键断裂

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202405197
Qin, Xuan; Wang, Yong; Ye, Qiuji; Hakenjos, John M; Wang, Jin; Teng, Mingxing; Guo, Lei; Tan, Zhi; Young, Damian W; MacKenzie, Kevin R; Li, Feng
代谢
发表日期：2024
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Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology.

利用DNA编码化学技术发现高效且对ALK2/ALK1具有选择性的激酶抑制剂

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2413108121
Jimmidi Ravikumar, Monsivais Diana, Ta Hai Minh, Sharma Kiran L, Bohren Kurt M, Chamakuri Srinivas, Liao Zian, Li Feng, Hakenjos John M, Li Jian-Yuan, Mishina Yuji, Pan Haichun, Qin Xuan, Robers Matthew B, Sankaran Banumathi, Tan Zhi, Tang Suni, Vasquez Yasmin M, Wilkinson Jennifer, Young Damian W, Palmer Stephen S, MacKenzie Kevin R, Kim Choel, Matzuk Martin M
其它
发表日期：2024
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Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy

具有改进的药代动力学特性和抗癌功效的SRC-3抑制剂先导化合物开发

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.3c01596
Lu, Dong; Chen, Jianwei; Qin, Li; Bijou, Imani; Yi, Ping; Li, Feng; Song, Xianzhou; MacKenzie, Kevin R; Yu, Xin; Yang, Bin; Roy Chowdhury, Sandipan; Korp, James D; O'Malley, Bert W; Lonard, David M; Wang, Jin
SRC
肿瘤
肿瘤免疫
发表日期：2024
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Expanding Complex Morpholines Using Systematic Chemical Diversity

利用系统化学多样性扩展复杂吗啉

期刊:Organic Letters
影响因子:5
doi:10.1021/acs.orglett.4c00528
Tang, Sunny Ann; Fults, Afton; Boyd, Shelton R; Gattu, Nikhil; Tran, Kevin A; Fan, Jiayi; MacKenzie, Kevin R; Palzkill, Timothy; Young, Damian W; Chamakuri, Srinivas
发表日期：2024
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CYP3A-Mediated Carbon-Carbon Bond Cleavages in Drug Metabolism

CYP3A介导的药物代谢中的碳-碳键断裂

期刊:Biomolecules
影响因子:4.8
doi:10.3390/biom14091125
Zhou, Junhui; Qin, Xuan; Zhou, Shenzhi; MacKenzie, Kevin R; Li, Feng
代谢
发表日期：2024
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Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1

化学催化指导BET抑制剂JQ1主要体内代谢物的结构鉴定

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.3c00464
Holmes, Secondra; Jain, Prashi; Rodriguez, Kenneth Guzman; Williams, Jade; Yu, Zhifeng; Cerda-Smith, Christian; Samuel, Errol L G; Campbell, James; Hakenjos, John Michael; Monsivais, Diana; Li, Feng; Chamakuri, Srinivas; Matzuk, Martin M; Santini, Conrad; MacKenzie, Kevin R; Young, Damian W
代谢
发表日期：2024
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MALDI Imaging Mass Spectrometry Visualizes the Distribution of Antidepressant Duloxetine and Its Major Metabolites in Mouse Brain, Liver, Kidney, and Spleen Tissues

MALDI成像质谱技术可视化抗抑郁药度洛西汀及其主要代谢物在小鼠脑、肝、肾、脾组织中的分布

期刊:Drug Metabolism and Disposition
影响因子:4
doi:10.1124/dmd.124.001719
Khalil, Saleh M; Qin, Xuan; Hakenjos, John M; Wang, Jian; Hu, Zhaoyong; Liu, Xinli; Wang, Jin; Maletic-Savatic, Mirjana; MacKenzie, Kevin R; Matzuk, Martin M; Li, Feng
Mouse
神经科学
代谢
发表日期：2024
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Metabolic bioactivation of antidepressants: advance and underlying hepatotoxicity

抗抑郁药的代谢生物活化：进展及潜在的肝毒性

期刊:Drug Metabolism Reviews
影响因子:3.8
doi:10.1080/03602532.2024.2313967
Khalil, Saleh M; MacKenzie, Kevin R; Maletic-Savatic, Mirjana; Li, Feng
毒理研究
神经科学
代谢
发表日期：2024
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