日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SARS-CoV-2 3CL-protease inhibitors derived from ML300: investigation of P1 and replacements of the 1,2,3-benzotriazole

源自ML300的SARS-CoV-2 3CL蛋白酶抑制剂:P1的研究及1,2,3-苯并三唑的替代

Hooper, Alice; Macdonald, Jonathan D; Reilly, Brenna; Maw, Joshua; Wirrick, Aidan P; Han, Sang Hoon; Lindsey, A Abigail; Rico, Emma G; Romigh, Todd; Goins, Christopher M; Wang, Nancy S; Stauffer, Shaun

Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL(pro))

基于结构的ML300衍生非共价抑制剂靶向严重急性呼吸综合征冠状病毒3CL蛋白酶(SARS-CoV-2 3CL(pro))的优化

Han, Sang Hoon; Goins, Christopher M; Arya, Tarun; Shin, Woo-Jin; Maw, Joshua; Hooper, Alice; Sonawane, Dhiraj P; Porter, Matthew R; Bannister, Breyanne E; Crouch, Rachel D; Lindsey, A Abigail; Lakatos, Gabriella; Martinez, Steven R; Alvarado, Joseph; Akers, Wendell S; Wang, Nancy S; Jung, Jae U; Macdonald, Jonathan D; Stauffer, Shaun R

Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.

发现和基于结构的强效选择性 WD 重复结构域 5 (WDR5) 抑制剂,该抑制剂含有二氢异喹啉酮双环核心

Tian Jianhua, Teuscher Kevin B, Aho Erin R, Alvarado Joseph R, Mills Jonathan J, Meyers Kenneth M, Gogliotti Rocco D, Han Changho, Macdonald Jonathan D, Sai Jiqing, Shaw J Grace, Sensintaffar John L, Zhao Bin, Rietz Tyson A, Thomas Lance R, Payne William G, Moore William J, Stott Gordon M, Kondo Jumpei, Inoue Masahiro, Coffey Robert J, Tansey William P, Stauffer Shaun R, Lee Taekyu, Fesik Stephen W

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

利用基于片段的方法和基于结构的设计发现强效的2-芳基-6,7-二氢-5H-吡咯并[1,2-a]咪唑类化合物作为WDR5-WIN位点抑制剂

Wang, Feng; Jeon, Kyu Ok; Salovich, James M; Macdonald, Jonathan D; Alvarado, Joseph; Gogliotti, Rocco D; Phan, Jason; Olejniczak, Edward T; Sun, Qi; Wang, Shidong; Camper, DeMarco; Yuh, Joannes P; Shaw, J Grace; Sai, Jiqing; Rossanese, Olivia W; Tansey, William P; Stauffer, Shaun R; Fesik, Stephen W