Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein.
基于硫醇的化学探针通过变构破坏刺突糖蛋白中的二硫键,对 SARS-CoV-2 表现出抗病毒活性
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2120419119
Shi Yunlong, Zeida Ari, Edwards Caitlin E, Mallory Michael L, Sastre Santiago, Machado MatÃas R, Pickles Raymond J, Fu Ling, Liu Keke, Yang Jing, Baric Ralph S, Boucher Richard C, Radi Rafael, Carroll Kate S