日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of small molecules and a druggable groove that regulate DNA binding and release of the AP-1 transcription factor ΔFOSB

发现能够调控AP-1转录因子ΔFOSB的DNA结合和释放的小分子和可成药沟槽

McNeme, Sean; Yim, Yun Young; Kumar, Ashwani; Li, Yi; Hughes, Brandon; St Romain, Corey Peyton; Aglyamova, Galina; Chen, Jianping; Nguyen, Nghi D; Fan, Shanghua; Stephens, Gabriel S; Zhao, Wen-Ning; Kruzshak, Samantha; Estill, Molly; Brener, Corrine; Tofani, Solange; Kumar, Anil; Chen, Earnest P; Takatka, Nadeen; Robison, Alfred J; Chen, Haiying; Powell, Reid T; Haggarty, Stephen J; Stephan, Clifford; Nestler, Eric J; Chin, Jeannie; Machius, Mischa; Zhou, Jia; Rudenko, Gabby

Efficient in vivo pharmacological inhibition of ΔFOSB, an AP1 transcription factor, in brain

脑内高效药理学抑制ΔFOSB(一种AP1转录因子)

McNeme, Sean; Kumar, Anil; Yim, Yun Young; Hughes, Brandon W; St Romain, Corey; Li, Yi; Kumar, Ashwani; Bao, Qichao; Estill, Molly; Fan, Shanghua; Takatka, Nadeen; Chen, Earnest P; Rivera, Matthew; Chen, Haiying; Robison, Alfred J; Machius, Mischa; Haggarty, Steve J; Chin, Jeannie; Nestler, Eric J; Zhou, Jia; Rudenko, Gabby

Designer molecules of the synaptic organizer MDGA1 reveal 3D conformational control of biological function

突触组织者 MDGA1 的设计分子揭示了生物功能的 3D 构象控制

Hubert Lee, Nicolas Chofflet, Jianfang Liu, Shanghua Fan, Zhuoyang Lu, Martin Resua Rojas, Patrick Penndorf, Aaron O Bailey, William K Russell, Mischa Machius, Gang Ren, Hideto Takahashi, Gabby Rudenko

Interplay between hevin, SPARC, and MDGAs: Modulators of neurexin-neuroligin transsynaptic bridges

Hevin、SPARC 和 MDGA 之间的相互作用:神经连接蛋白-神经胶质蛋白跨突触桥的调节剂

Shanghua Fan, Shanti Pal Gangwar, Mischa Machius, Gabby Rudenko

Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes

IgLON 中高度保守的分子特征与其独特的结构和生物学结果形成对比

Harikanth Venkannagari, James M Kasper, Anurag Misra, Scott A Rush, Shanghua Fan, Hubert Lee, Hong Sun, Suchithra Seshadrinathan, Mischa Machius, Jonathan D Hommel, Gabby Rudenko

Self-assembly of the bZIP transcription factor ΔFosB

bZIP 转录因子 ΔFosB 的自组装

Zhou Yin, Harikanth Venkannagari, Haley Lynch, Galina Aglyamova, Mukund Bhandari, Mischa Machius, Eric J Nestler, Alfred J Robison, Gabby Rudenko

Activator Protein-1: redox switch controlling structure and DNA-binding

激活蛋白-1:氧化还原开关控制结构和 DNA 结合

Zhou Yin, Mischa Machius, Eric J Nestler, Gabby Rudenko

Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges

MDGA1的分子机制:神经连接蛋白2:神经连接蛋白跨突触桥的调控

Gangwar, Shanti Pal; Zhong, Xiaoying; Seshadrinathan, Suchithra; Chen, Hui; Machius, Mischa; Rudenko, Gabby

Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity

精神分裂症中发现的罕见变异的功能分析表明 GIT1-PAK3 信号在神经可塑性中起着关键作用

M J Kim, J Biag, D M Fass, M C Lewis, Q Zhang, M Fleishman, S P Gangwar, M Machius, M Fromer, S M Purcell, S A McCarroll, G Rudenko, R T Premont, E M Scolnick, S J Haggarty

Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors

发现大环嘧啶类化合物作为MerTK特异性抑制剂

McIver, Andrew L; Zhang, Weihe; Liu, Qingyang; Jiang, Xinpeng; Stashko, Michael A; Nichols, James; Miley, Michael J; Norris-Drouin, Jacqueline; Machius, Mischa; DeRyckere, Deborah; Wood, Edgar; Graham, Douglas K; Earp, H Shelton; Kireev, Dmitri; Frye, Stephen V; Wang, Xiaodong