日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanding the payload scope in antibody-drug conjugates by delivery of hydroxy-containing drugs through self-immolative phosphoramidates

通过自裂解磷酰胺递送含羟基药物,扩大抗体药物偶联物的有效载荷范围

Ochtrop, Philipp; Jagtap, Anil P; Felber, Jan G; Vogt, Simon; Herterich, Sarah; Mai, Isabelle; Cyprys, Philipp; Schmitt, Saskia; Payer, Sarah; Kitowski, Annabel; Wunder, Swetlana; Machui, Paul; Brandmeier, Julia; Leonardi, Natascia; Poliak, Elizaveta; Hackenberger, Christian P R; Marcq, Olivier; Schumacher, Dominik; Helma, Jonas; Vogl, Annette M; Kasper, Marc-André

TUB-040, a Homogeneous and Hydrophilic NaPi2b-Targeting ADC with Stably Linked Exatecan, Exhibits Long-lasting Antitumor Activity and a Well-Tolerated Safety Profile.

TUB-040 是一种均质亲水性 NaPi2b 靶向 ADC,其稳定连接了依沙替康,具有持久的抗肿瘤活性和良好的耐受性安全性。

Vogl Annette M, Schmitt Saskia, Mai Isabelle, Machui Paul, Herterich Sarah, Leonardi Natascia, Cyprys Philipp, Hauswald Danila, Ochtrop Philipp, Kozlowska Izabela, Kitowski Annabel, Gerlach Marcus, Waldmann Florian, Marcq Olivier, Trail Pamela A, Schumacher Dominik, Fingerle-Rowson Günter R, Hock Björn, Kasper Marc-André, Helma Jonas

Circulating C-terminal peptides and polymers of alpha-1 antitrypsin as putative markers of pediatric Pi*ZZ liver disease

循环中α1-抗胰蛋白酶C端肽和聚合物作为儿童Pi*ZZ肝病的潜在标志物

Katzer, David; Börner, Friedemann Robert; Weigert, Alexander; Held, Julia; Bagci, Soyhan; Ganschow, Rainer; Mielczarek, Pia; Machui, Alexander; Kiehntopf, Michael; Janciauskiene, Sabina

Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody-Drug Conjugates

膦酰胺连接的依沙替康构建体的设计与评价及其在高载药量、稳定性和高效抗体-药物偶联物中的应用

Schmitt, Saskia; Machui, Paul; Mai, Isabelle; Herterich, Sarah; Wunder, Swetlana; Cyprys, Philipp; Gerlach, Marcus; Ochtrop, Philipp; Hackenberger, Christian P R; Schumacher, Dominik; Helma, Jonas; Vogl, Annette M; Kasper, Marc-André

Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile

结构紧凑的亲水性亲电试剂能够制备高效、高药物抗体比(DAR)且具有优异体内药代动力学特征的抗体药物偶联物(ADC)。

Ochtrop, Philipp; Jahzerah, Jahaziel; Machui, Paul; Mai, Isabelle; Schumacher, Dominik; Helma, Jonas; Kasper, Marc-André; Hackenberger, Christian P R