日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice

人类BPIFB4基因的一种与长寿相关的变异体可预防早衰小鼠的舒张功能障碍。

Qiu, Yan; Cattaneo, Monica; Maciag, Anna; Puca, Annibale A; Madeddu, Paolo

Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.

发现 BBO-8520,一种首创的直接共价双重抑制剂,可抑制 GTP 结合 (ON) 和 GDP 结合 (OFF) 的 KRASG12C

Maciag Anna E, Stice James P, Wang Bin, Sharma Alok K, Chan Albert H, Lin Ken, Singh Devansh, Dyba Marcin, Yang Yue, Setoodeh Saman, Smith Brian P, Ju Jin Hyun, Jeknic Stevan, Rabara Dana, Zhang Zuhui, Larsen Erik K, Esposito Dominic, Denson John-Paul, Ranieri Michela, Meynardie Mary, Mehdizadeh Sadaf, Alexander Patrick A, Abreu Blanco Maria, Turner David M, Xu Rui, Lightstone Felice C, Wong Kwok-Kin, Stephen Andrew G, Wang Keshi, Simanshu Dhirendra K, Sinkevicius Kerstin W, Nissley Dwight V, Wallace Eli, McCormick Frank, Beltran Pedro J

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

通过对 CaaX 盒半胱氨酸进行直接共价攻击,阻断 KRAS4b 的 C 端加工

Maciag Anna E, Yang Yue, Sharma Alok K, Turner David M, DeHart Caroline J, Abdelkarim Hazem, Fan Lixin, Smith Brian P, Kumari Vandana, Dyba Marcin, Rigby Megan, Castillo Badillo Jean A, Adams Lauren, Fornelli Luca, Fox Stephen, Brafman Alla, Turbyville Thomas, Gillette William, Messing Simon, Agamasu Constance, Wolfe Andrew L, Gysin Stephan, Chan Albert H, Simanshu Dhirendra K, Esposito Dominic, Chertov Oleg, Stephen Andrew G, Arkin Michelle, Renslo Adam, Kelleher Neil L, Gaponenko Vadim, Lightstone Felice C, Nissley Dwight V, McCormick Frank

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

对KRAS开关II口袋抑制剂的生物物理和结构分析揭示了等位基因特异性结合限制。

Alexander, Patrick; Chan, Albert H; Rabara, Dana; Swain, Monalisa; Larsen, Erik K; Dyba, Marcin; Chertov, Oleg; Ashraf, Mariam; Champagne, Allison; Lin, Ken; Maciag, Anna; Gillette, William K; Nissley, Dwight V; McCormick, Frank; Simanshu, Dhirendra K; Stephen, Andrew G

The Genetic and Epigenetic Arms of Human Ageing and Longevity

人类衰老和长寿的遗传和表观遗传机制

Ciaglia, Elena; Montella, Francesco; Lopardo, Valentina; Basile, Cristina; Esposito, Roberta Maria; Maglio, Clara; Longo, Roberta; Maciag, Anna; Puca, Annibale Alessandro

NMR (1)H, (13)C, and (15)N resonance assignments of the oncogenic Q61R variant of human NRAS in the active, GTP-bound conformation

人类 NRAS 致癌 Q61R 变体在活性 GTP 结合构象下的 NMR (1)H、(13)C 和 (15)N 共振归属

Sharma, Alok K; Tonelli, Marco; Dyba, Marcin; Gillette, William K; Esposito, Dominic; Nissley, Dwight V; McCormick, Frank; Maciag, Anna E

A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement

自上而下的蛋白质组学分析评估KRAS4B-化合物相互作用

D'Ippolito, Robert A; Rabara, Dana; Blanco, Maria Abreu; Alberico, Emily; Drew, Matthew R; Ramakrishnan, Nitya; Sontan, Dara; Widmeyer, Stephanie R T; Scheidemantle, Grace M; Messing, Simon; Turner, David; Arkin, Michelle; Maciag, Anna E; Stephen, Andrew G; Esposito, Dominic; McCormick, Frank; Nissley, Dwight V; DeHart, Caroline J

The longevity-associated BPIFB4 gene guarantees vascular homeostasis and immune protection through platelets

与长寿相关的BPIFB4基因通过血小板保证血管稳态和免疫保护。

Ciaglia, Elena; Montella, Francesco; Carrizzo, Albino; Lopardo, Valentina; Esposito, Roberta Maria; Basile, Cristina; Damato, Antonio; De Lucia, Massimiliano; Maciag, Anna; Spinetti, Gaia; Milella, Maria Serena; Maselli, Davide; Vecchione, Carmine; Puca, Annibale Alessandro

Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by (31)P NMR

利用 (31)P NMR 揭示首创的 KRASG12C (ON) 共价抑制剂的作用机制以及致癌 KRAS 的其他功能特性

Sharma, Alok K; Pei, Jun; Yang, Yue; Dyba, Marcin; Smith, Brian; Rabara, Dana; Larsen, Erik K; Lightstone, Felice C; Esposito, Dominic; Stephen, Andrew G; Wang, Bin; Beltran, Pedro J; Wallace, Eli; Nissley, Dwight V; McCormick, Frank; Maciag, Anna E

The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy

与长寿相关的BPIFB4基因支持衰老性心肌病中的心脏功能和血管生成。

Cattaneo, Monica; Beltrami, Antonio P; Thomas, Anita C; Spinetti, Gaia; Alvino, Valeria Vincenza; Avolio, Elisa; Veneziano, Claudia; Rolle, Irene Giulia; Sponga, Sandro; Sangalli, Elena; Maciag, Anna; Dal Piaz, Fabrizio; Vecchione, Carmine; Alenezi, Aishah; Paisey, Stephen; Puca, Annibale A; Madeddu, Paolo