日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.

一种新型PLpro抑制剂改善了新冠肺炎长期症状的临床前模型的结果

M Bader Stefanie, Calleja Dale J, Devine Shane M, Kuchel Nathan W, Lu Bernadine G C, Wu Xinyu, Birkinshaw Richard W, Bhandari Reet, Loi Katie, Volpe Rohan, Khakham Yelena, Au Amanda E, Blackmore Timothy R, Mackiewicz Liana, Dayton Merle, Schaefer Jan, Scherer Lena, Stock Angus T, Cooney James P, Schoffer Kael, Maluenda Ana, Kleeman Elizabeth A, Davidson Kathryn C, Allison Cody C, Ebert Gregor, Chen Gong, Katneni Kasiram, Klemm Theresa A, Nachbur Ueli, Georgy Smitha Rose, Czabotar Peter E, Hannan Anthony J, Putoczki Tracy L, Tanzer Maria, Pellegrini Marc, Lechtenberg Bernhard C, Charman Susan A, Call Melissa J, Mitchell Jeffrey P, Lowes Kym N, Lessene Guillaume, Doerflinger Marcel, Komander David

IL-1β drives SARS-CoV-2-induced disease independently of the inflammasome and pyroptosis signalling.

IL-1β 驱动 SARS-CoV-2 引起的疾病,与炎症小体和细胞焦亡信号无关

M Bader Stefanie, Scherer Lena, Schaefer Jan, Cooney James P, Mackiewicz Liana, Dayton Merle, Georgy Smitha Rose, Davidson Kathryn C, Allison Cody C, Herold Marco J, Strasser Andreas, Pellegrini Marc, Doerflinger Marcel

Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection

短暂抑制I型干扰素可增强CD8+ T细胞干性及疫苗保护作用

Broomfield, Benjamin J; Tan, Chin Wee; Qin, Raymond Z; Abberger, Hanna; Duckworth, Brigette C; Alvarado, Carolina; Dalit, Lennard; Lee, Chee Leng; Shandre Mugan, Rekha; Mazrad, Zihnil A I; Muramatsu, Hiromi; Mackiewicz, Liana; Williams, Bailey E; Chen, Jinjin; Takanashi, Asuka; Fabb, Stewart; Pellegrini, Marc; Rogers, Kelly L; Moon, Woohyun J; Pouton, Colin W; Davis, Melissa J; Nutt, Stephen L; Pardi, Norbert; Wimmer, Verena C; Groom, Joanna R

Transient inhibition of type I interferon enhances CD8 (+) T cell stemness and vaccine protection

短暂抑制I型干扰素可增强CD8(+)T细胞干性及疫苗保护作用

Broomfield, Benjamin J; Tan, Chin Wee; Qin, Raymond Z; Duckworth, Brigette C; Alvarado, Carolina; Dalit, Lennard; Chen, Jinjin; Mackiewicz, Liana; Muramatsu, Hiromi; Pellegrini, Marc; Rogers, Kelly L; Moon, Woohyun J; Nutt, Stephen L; Davis, Melissa J; Pardi, Norbert; Wimmer, Verena C; Groom, Joanna R

Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models.

临床 MDR1 抑制剂可增强 Smac 模拟物的生物利用度,从而杀死小鼠 LSC 并提高 AML 模型中的生存率

Morrish Emma, Copeland Anthony, Moujalled Donia M, Powell Jason A, Silke Natasha, Lin Ann, Jarman Kate E, Sandow Jarrod J, Ebert Gregor, Mackiewicz Liana, Beach Jessica A, Christie Elizabeth L, Lewis Alexander C, Pomilio Giovanna, Fischer Karla C, MacPherson Laura, Bowtell David D L, Webb Andrew I, Pellegrini Marc, Dawson Mark A, Pitson Stuart M, Wei Andrew H, Silke John, Brumatti Gabriela