日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA-Mutated Solid Tumors and in Preclinical Models.

PI3Kα抑制剂和降解剂Inavolisib可利用FGFR2增强PIK3CA突变实体瘤患者和临床前模型的疗效。

Juric Dejan, Song Kyung, Johnson Radia M, Accordino Melissa K, Bedard Philippe L, Cervantes Andrés, Gambardella Valentina, Hamilton Erika, Italiano Antoine, Kalinsky Kevin, Krop Ian E, Oliveira Mafalda, Saura Cristina, Schmid Peter, Turner Nicholas C, Varga Andreea, Gendreau Steven, Hwang Michael S, Kuang Zheng, Lau Jeffrey T, Lin Eva, Pham Trang, Maddalo Danilo, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Martin Scott, Sodir Nicole M, Sokol Ethan S, Whitfield Zachary J, Wong Alice, Yauch Robert L, Aimi Junko, Cheeti Sravanthi, Fredrickson Jill, Hilz Stephanie, Hafner Marc, Hutchinson Katherine E, Jin Yanling, Peters Ubong, Zingg Daniel, Royer-Joo Stephanie, Shankar Noopur, Schutzman Jennifer L, Jhaveri Komal L, Dey Anwesha

Author Correction: Targeting the SHOC2-RAS interaction in RAS-mutant cancers

作者更正:靶向 RAS 突变癌症中的 SHOC2-RAS 相互作用

Hauseman, Zachary J; Stauffer, Frédéric; Beyer, Kim S; Mollé, Sandra; Cavicchioli, Elena; Marchand, Jean-Remy; Fodor, Michelle; Viscomi, Jessica; Dhembi, Anxhela; Katz, Stéphanie; Faggion, Beatrice; Lanter, Mylene; Kerr, Grainne; Schildknecht, Daniela; Handl, Cornelia; Maddalo, Danilo; Pissot Soldermann, Carole; Brady, Jacob; Shrestha, Om; Nguyen, Zachary; Leder, Lukas; Cremosnik, Gregor; Lopez Romero, Sandra; Hassiepen, Ulrich; Stams, Travis; Linder, Markus; Galli, Giorgio G; Guthy, Daniel A; King, Daniel A; Maira, Sauveur-Michel; Thoma, Claudio R; Ehmke, Veronika; Tordella, Luca

Targeting the SHOC2-RAS interaction in RAS-mutant cancers.

靶向 RAS 突变癌症中的 SHOC2-RAS 相互作用

Hauseman Zachary J, Stauffer Frédéric, Beyer Kim S, Mollé Sandra, Cavicchioli Elena, Marchand Jean-Remy, Fodor Michelle, Viscomi Jessica, Dhembi Anxhela, Katz Stéphanie, Faggion Beatrice, Lanter Mylene, Kerr Grainne, Schildknecht Daniela, Handl Cornelia, Maddalo Danilo, Pissot Soldermann Carole, Brady Jacob, Shrestha Om, Nguyen Zachary, Leder Lukas, Cremosnik Gregor, Lopez Romero Sandra, Hassiepen Ulrich, Stams Travis, Linder Markus, Galli Giorgio G, Guthy Daniel A, King Daniel A, Maira Sauveur-Michel, Thoma Claudio R, Ehmke Veronika, Tordella Luca

Fragment-based discovery enables direct targeting of the melanoma oncogene MITF

基于片段的发现能够直接靶向黑色素瘤癌基因MITF。

Castelletti, Deborah; Hinrichs, Jürgen; Malojčić, Goran; Ji, Fei; Desplat, Aurore; Reimer, Bryn; Henry, Christelle; Porter, Kathryn A; Mermet-Meillon, Fanny; Wartmann, Markus; Wirth, Emmanuelle; Delmas, Cécile; Fernández, César; Mayer, Philipp H O; Schmiedeberg, Niko; Plattner, Simone; Brun, Jvan; Kläusler, Stephan; Kurmann, Jessica; Yan, Kelly; Fuller, John; Schaeffer, Fanny; Maddalo, Danilo; Altorfer, Marc; Piperidou, Nikoletta; Pautrieux, Nicolas; Baysang, Frederic; Kaufmann, Markus; Cobos-Correa, Amanda; Wilcken, Rainer; Renatus, Martin; Vulpetti, Anna; Jahnke, Wolfgang

KRAS Codon-Specific Mutations Differentially Toggle PI3K Pathway Signaling and Alter Sensitivity to Inavolisib (GDC-0077).

KRAS 密码子特异性突变差异性地切换 PI3K 通路信号传导并改变对 Inavolisib (GDC-0077) 的敏感性。

Song Kyung W, Ong Christy C, Lin Eva, Lau Jeff, Sodir Nicole M, Jin Dexter X, Hutchinson Katherine E, Xie Shiqi, Tan Jenille, Liang Yuxin, Modrusan Zora, Martin Scott E, Maddalo Danilo, Hafner Marc, Dey Anwesha

EXTH-57. Evaluation of a novel CNS penetrant YAP/TEAD-targeted therapy for lung cancer brain metastases

EXTH-57. 新型中枢神经系统穿透性YAP/TEAD靶向疗法治疗肺癌脑转移的评价

Yang, Huan; Zhou, Ting; Kim, Jooyong; Liu, Bo; Torrini, Consuelo; Nayyar, Naema; Hagenbeek, Thijs; Yamazawa, Erika; Summers, Elizabeth; Maddalo, Danilo; Wakimoto, Hiroaki; Dey, Anwesha; Brastianos, Priscilla

SHP2: A Pleiotropic Target at the Interface of Cancer and Its Microenvironment

SHP2:癌症及其微环境交界处的多效性靶点

Sodir, Nicole M; Pathria, Gaurav; Adamkewicz, Joanne I; Kelley, Elizabeth H; Sudhamsu, Jawahar; Merchant, Mark; Chiarle, Roberto; Maddalo, Danilo

Applications of CRISPR-Cas9 for advancing precision medicine in oncology: from target discovery to disease modeling

CRISPR-Cas9在肿瘤精准医疗中的应用:从靶点发现到疾病建模

Ravichandran, Mirunalini; Maddalo, Danilo

SALL4B, not targeted by IMiD, is important for SALL4-mediated tumorigenesis

SALL4B 不是 IMiD 的靶点,但它对 SALL4 介导的肿瘤发生至关重要。

L Vu, Kim Anh; Kumari, Kalpana; Liu, Bee Hui; Gao, Chong; Li, Feng; Tang, Jing Ping; Maddalo, Danilo; Auld, Douglas S; Casalena, Dominick E; Tian, Xi; Liu, Miao; Bassal, Mahmoud A; Moein, Shiva; Iakovleva, Viktoriia; Tan, Justin L; Stein, Alicia J; Zhou, Qiling; Fischer, Patrick D; Sigua, Logan H; Qi, Jun; Arthanari, Haribabu; Tenen, Daniel G; Chai, Li

SEMMs: Somatically Engineered Mouse Models. A New Tool for In Vivo Disease Modeling for Basic and Translational Research

SEMMs:体细胞工程小鼠模型。一种用于基础和转化研究的体内疾病建模新工具

Lima, Anthony; Maddalo, Danilo