日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Yersinia pestis effector YopM binds the human pyrin death domain to inhibit inflammasome activation and effector-triggered immunity

鼠疫耶尔森菌效应蛋白YopM与人pyrin死亡结构域结合,从而抑制炎症小体活化和效应蛋白触发的免疫反应。

Mwaura, Bethany W; Simard, Adam R; Pettis, Morgan L; Liu, Ao; Madden, Dean R; Bliska, James B

Convergent strategies for nanobody-mediated inhibition of an epoxide hydrolase

纳米抗体介导的环氧化物水解酶抑制的汇聚策略

Simard, Adam R; Taher, Noor M; Beauchemin, Kathryn S; Mishra, Akaash K; Hederman, Andrew P; Hampton, Thomas H; Vasylieva, Natalia; Morisseau, Christophe; Ackerman, Margaret E; Madden, Dean R

Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context

对非基序调节残基进行序列工程改造,可得到一种肽,该肽能够有效靶向疾病相关细胞环境中的单个PDZ蛋白。

Amacher, Jeanine F; Cushing, Patrick R; Vouilleme, Lars; Cullati, Sierra N; Deng, Bin; Gerber, Scott A; Boisguerin, Prisca; Madden, Dean R

Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions

用于研究囊性纤维化慢性多微生物感染的模型系统:当前方法及未来方向探索

O'Toole, George A; Crabbé, Aurélie; Kümmerli, Rolf; LiPuma, John J; Bomberger, Jennifer M; Davies, Jane C; Limoli, Dominique; Phelan, Vanessa V; Bliska, James B; DePas, William H; Dietrich, Lars E; Hampton, Thomas H; Hunter, Ryan; Khursigara, Cezar M; Price-Whelan, Alexa; Ashare, Alix; Cramer, Robert A; Goldberg, Joanna B; Harrison, Freya; Hogan, Deborah A; Henson, Michael A; Madden, Dean R; Mayers, Jared R; Nadell, Carey; Newman, Dianne; Prince, Alice; Rivett, Damian W; Schwartzman, Joseph D; Schultz, Daniel; Sheppard, Donald C; Smyth, Alan R; Spero, Melanie A; Stanton, Bruce A; Turner, Paul E; van der Gast, Chris; Whelan, Fiona J; Whitaker, Rachel; Whiteson, Katrine

Specificity in PDZ-peptide interaction networks: Computational analysis and review

PDZ肽相互作用网络的特异性:计算分析与综述

Amacher, Jeanine F; Brooks, Lionel; Hampton, Thomas H; Madden, Dean R

Correction to "A Compact Structure of Cytochrome c Trapped in a Lysine-Ligated State: Loop Refolding and Functional Implications of a Conformational Switch"

对“细胞色素c在赖氨酸连接状态下的紧凑结构:环重折叠和构象转换的功能意义”一文的更正

Amacher, Jeanine F; Zhong, Fangfang; Lisi, George P; Zhu, Michael Q; Alden, Stephanie L; Hoke, Kevin R; Madden, Dean R; Pletneva, Ekaterina V

Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain

更正:半胱氨酸修饰揭示了CAL PDZ结构域上的变构抑制位点。

Zhao, Yu; Cushing, Patrick R; Smithson, David C; Pellegrini, Maria; Pletnev, Alexandre A; Al-Ayyoubi, Sahar; Grassetti, Andrew V; Gerber, Scott A; Guy, R Kiplin; Madden, Dean R

Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain

半胱氨酸修饰物提示CAL PDZ结构域上存在变构抑制位点。

Zhao, Yu; Cushing, Patrick R; Smithson, David C; Pellegrini, Maria; Pletnev, Alexandre A; Al-Ayyoubi, Sahar; Grassetti, Andrew V; Gerber, Scott A; Guy, R Kiplin; Madden, Dean R

An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung

铜绿假单胞菌分泌的一种环氧化物水解酶会降低黏液纤毛清除功能,阻碍肺部细菌的清除。

Hvorecny, Kelli L; Dolben, Emily; Moreau-Marquis, Sophie; Hampton, Thomas H; Shabaneh, Tamer B; Flitter, Becca A; Bahl, Christopher D; Bomberger, Jennifer M; Levy, Bruce D; Stanton, Bruce A; Hogan, Deborah A; Madden, Dean R

Optimization of the process of inverted peptides (PIPE(PLUS)) to screen PDZ domain ligands

优化反向肽(PIPE(PLUS))筛选PDZ结构域配体的过程

Seisel, Quentin; Rädisch, Marisa; Gill, Nicholas P; Madden, Dean R; Boisguerin, Prisca