日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas

ALDH1L2 调节胰腺中的活性氧和腺泡-导管化生

Hennequart, Marc; Mervant, Loic; Stockis, Julie; Coomes, Jack; Zarou, Martha M; Gerard, Louise; Tevel, Virginie; Migeot, Valérie; Pilley, Steven E; Lee, Younghwan; Driscoll, Paul C; Legrave, Nathalie M; Labuschagne, Christiaan F; Zani, Fabio; Uribe, Alejandro Huerta; Ferreira, Rute Machado De Morais; Cheung, Eric C; Malanchi, Ilaria; MacRae, James I; Maddocks, Oliver D K; Halim, Timotheus Y F; Vousden, Karen H

Colon cancer cells evade drug action by enhancing drug metabolism.

结肠癌细胞通过增强药物代谢来逃避药物作用

Cong Bojie, Thakur Teena, Uribe Alejandro Huerta, Stamou Evangelia, Gopinath Sindhura, Sansom Owen, Maddocks Oliver, Cagan Ross

Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models.

针对 mTORC1、mTORC2 和 PI3Kα 的多节点抑制可有效抑制子宫内膜癌和乳腺癌模型中的 PI3K/AKT/mTOR 通路

Tyrakis Petros A, Kampjut Domen, Steele Georgina F, Lindström H Jonathan G, Chirnomas Deborah, Hopkins Benjamin D, Goncalves Marcus D, Mukherjee Siddhartha, Cantley Lewis C, Maddocks Oliver D K

Developmental mitochondrial complex I activity determines lifespan.

发育过程中线粒体复合物 I 的活性决定寿命

Stefanatos Rhoda, Robertson Fiona, Castejon-Vega Beatriz, Yu Yizhou, Uribe Alejandro Huerta, Myers Kevin, Kataura Tetsushi, Korolchuk Viktor I, Maddocks Oliver D K, Martins L Miguel, Sanz Alberto

Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies.

线粒体 ROS 信号传导需要不间断的电子流,而果蝇衰老过程中这种信号传导会丧失

Graham Charlotte, Stefanatos Rhoda, Yek Angeline E H, Spriggs Ruth V, Loh Samantha H Y, Uribe Alejandro Huerta, Zhang Tong, Martins L Miguel, Maddocks Oliver D K, Scialo Filippo, Sanz Alberto

Engineered diets to improve cancer outcomes

改良饮食以改善癌症治疗效果

Goncalves, Marcus D; Maddocks, Oliver Dk

Assessment of Tumor Redox Status through (S)-4-(3-[(18)F]fluoropropyl)-L-Glutamic Acid PET Imaging of System x(c) (-) Activity

通过系统 x(c) (-) 活性的 (S)-4-(3-[(18)F]氟丙基)-L-谷氨酸 PET 成像评估肿瘤氧化还原状态

McCormick, Patrick N; Greenwood, Hannah E; Glaser, Matthias; Maddocks, Oliver D K; Gendron, Thibault; Sander, Kerstin; Gowrishankar, Gayatri; Hoehne, Aileen; Zhang, Tong; Shuhendler, Adam J; Lewis, David Y; Berndt, Mathias; Koglin, Norman; Lythgoe, Mark F; Gambhir, Sanjiv S; Årstad, Erik; Witney, Timothy H

One-carbon metabolism in cancer

癌症中的一碳代谢

Newman, Alice C; Maddocks, Oliver D K