日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

From DNA-Encoded Library Screening to AM-9747: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy.

从 DNA 编码文库筛选到 AM-9747:一种具有强效口服体内疗效的 MTA 协同 PRMT5 抑制剂

Sarvary Ian, Vestergaard Mikkel, Moretti Loris, Andersson Jan, Peiró Cadahía Jorge, Cowland Sanne, Flagstad Thomas, Franch Thomas, Gouliaev Alex, Husemoen Gitte, Jacso Tomas, Kronborg Titi, Kuropatnicka Aleksandra, Nadali Anna, Madsen Mads, Nielsen So Ren, Pii David, Ryborg So Ren, Soede Camillia, Allen Jennifer R, Bourbeau Matthew, Li Kexue, Liu Qingyian, Lo Mei-Chu, Madoux Franck, Mardirossian Narbe, Moriguchi Jodi, Ngo Rachel, Peng Chi-Chi, Pettus Liping, Tamayo Nuria, Wang Paul, Kapoor Rajiv, Belmontes Brian, Caenepeel Sean, Hughes Paul, Liu Siyuan, Slemmons Katherine K, Yang Yajing, Xie Fang, Ghimire-Rijal Sudipa, Mukund Susmith, Glad Sanne

Improved Scalability of Neuron-Based Phenotypic Screening Assays for Therapeutic Discovery in Neuropsychiatric Disorders

提高基于神经元的表型筛选检测方法在神经精神疾病治疗发现中的可扩展性

Spicer, Timothy P; Hubbs, Christopher; Vaissiere, Thomas; Collia, Deanna; Rojas, Camilo; Kilinc, Murat; Vick, Kyle; Madoux, Franck; Baillargeon, Pierre; Shumate, Justin; Martemyanov, Kirill A; Page, Damon T; Puthanveettil, Sathya; Hodder, Peter; Davis, Ronald; Miller, Courtney A; Scampavia, Louis; Rumbaugh, Gavin

Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle

内源性和合成的ABHD5配体调节ABHD5-Perilipin相互作用以及脂肪和肌肉中的脂肪分解

Sanders, Matthew A; Madoux, Franck; Mladenovic, Ljiljana; Zhang, Huamei; Ye, Xiangqun; Angrish, Michelle; Mottillo, Emilio P; Caruso, Joseph A; Halvorsen, Geoff; Roush, William R; Chase, Peter; Hodder, Peter; Granneman, James G

Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors

利用准不可逆硫醇修饰抑制剂选择性靶向细胞外胰岛素降解酶

Abdul-Hay, Samer O; Bannister, Thomas D; Wang, Hui; Cameron, Michael D; Caulfield, Thomas R; Masson, Amandine; Bertrand, Juliette; Howard, Erin A; McGuire, Michael P; Crisafulli, Umberto; Rosenberry, Terrone R; Topper, Caitlyn L; Thompson, Caroline R; Schürer, Stephan C; Madoux, Franck; Hodder, Peter; Leissring, Malcolm A

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4).

应用并行多参数细胞 FLIPR 检测分析鉴定毒蕈碱乙酰胆碱受体 4 (M4) 的调节剂

Smith Emery, Chase Peter, Niswender Colleen M, Utley Thomas J, Sheffler Douglas J, Noetzel Meredith J, Lamsal Atin, Wood Michael R, Conn P Jeffrey, Lindsley Craig W, Madoux Franck, Acosta Mary, Scampavia Louis, Spicer Timothy, Hodder Peter

A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs

FluoPol-ABPP PAD2 高通量筛选鉴定出首个靶向 PAD 的钙结合位点抑制剂

Lewallen, Daniel M; Bicker, Kevin L; Madoux, Franck; Chase, Peter; Anguish, Lynne; Coonrod, Scott; Hodder, Peter; Thompson, Paul R

Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation

抑制AMP化:一种用于鉴定首个蛋白质AMP化小分子抑制剂的新型筛选方法

Lewallen, Daniel M; Sreelatha, Anju; Dharmarajan, Venkatasubramanian; Madoux, Franck; Chase, Peter; Griffin, Patrick R; Orth, Kim; Hodder, Peter; Thompson, Paul R

Small-molecule proteostasis regulators for protein conformational diseases

用于蛋白质构象疾病的小分子蛋白质稳态调节剂

Calamini, Barbara; Silva, Maria Catarina; Madoux, Franck; Hutt, Darren M; Khanna, Shilpi; Chalfant, Monica A; Saldanha, S Adrian; Hodder, Peter; Tait, Bradley D; Garza, Dan; Balch, William E; Morimoto, Richard I

Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening

利用超高通量筛选鉴定结直肠癌癌基因Krüppel样因子5表达的小分子抑制剂

Bialkowska, Agnieszka B; Crisp, Melissa; Bannister, Thomas; He, Yuanjun; Chowdhury, Sarwat; Schürer, Stephan; Chase, Peter; Spicer, Timothy; Madoux, Franck; Tian, Chenlu; Hodder, Peter; Zaharevitz, Daniel; Yang, Vincent W

An ultra-high throughput cell-based screen for wee1 degradation inhibitors

一种用于筛选wee1降解抑制剂的超高通量细胞筛选方法

Madoux, Franck; Simanski, Scott; Chase, Peter; Mishra, Jitendra K; Roush, William R; Ayad, Nagi G; Hodder, Peter