日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology

[18F]ACI-19626 的开发:作为首个用于 TDP-43 病理成像的脑部 PET 示踪剂

Efthymia Vokali ,Elodie Chevalier ,Nicolas Dreyfus ,Dorian Charmey ,Tania Melly ,Jacqueline Kocher ,Monisha Ratnam ,Andreia M Serra ,Thomas Jaquier ,Christophe Delgado ,Myriam Ravache ,Carlo Scialò ,Sara Cappelli ,Heiko Kroth ,Francesca Capotosti ,Ruth Luthi-Carter ,Tariq Afroz ,Madiha Derouazi ,Cristian C Constantinescu ,Harro Seelaar ,Emanuele Buratti ,Peter T Nelson ,Magdalini Polymenidou ,Andrea Pfeifer ,Marie Kosco-Vilbois ,Tamara Seredenina

Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding

TDP-43与Tau蛋白的直接相互作用促进二者的共凝聚,同时抑制Tau蛋白原纤维的形成和成核作用。

Francesca Simonetti ,Weijia Zhong,Saskia Hutten,Federico Uliana,Martina Schifferer,Ali Rezaei,Lisa Marie Ramirez ,Janine Hochmair,Rithika Sankar,Anusha Gopalan ,Fridolin Kielisch,Henrick Riemenschneider,Viktoria Ruf,Carla Schmidt,Mikael Simons ,Markus Zweckstetter ,Susanne Wegmann,Tammaryn Lashley,Magdalini Polymenidou,Dieter Edbauer ,Dorothee Dormann

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD

人类神经网络模型揭示了肌萎缩侧索硬化症(ALS)和额颞叶痴呆(FTLD)中的NPTX2病理。

Marian Hruska-Plochan,Vera I Wiersma #,Katharina M Betz #,Izaskun Mallona #,Silvia Ronchi #,Zuzanna Maniecka,Eva-Maria Hock,Elena Tantardini,Florent Laferriere,Sonu Sahadevan,Vanessa Hoop,Igor Delvendahl,Manuela Pérez-Berlanga,Beatrice Gatta,Martina Panatta,Alexander van der Bourg,Dasa Bohaciakova,Puneet Sharma,Laura De Vos,Karl Frontzek,Adriano Aguzzi,Tammaryn Lashley,Mark D Robinson,Theofanis Karayannis,Martin Mueller,Andreas Hierlemann,Magdalini Polymenidou

Tau: a phase in the crowd

Tau:人群中的一个阶段

Vera I Wiersma, Ruben Rigort, Magdalini Polymenidou

An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation

一项全基因组扰动筛选实验表明,核糖核蛋白Hnrnpk是朊病毒传播的限速因子。

Merve Avar #,Daniel Heinzer #,Alana M Thackray,Yingjun Liu,Marian Hruska-Plochan,Stefano Sellitto,Elke Schaper,Daniel P Pease,Jiang-An Yin,Asvin Kk Lakkaraju,Marc Emmenegger,Marco Losa,Andra Chincisan,Simone Hornemann,Magdalini Polymenidou,Raymond Bujdoso,Adriano Aguzzi

Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS

突触 FUS 积累引发 ALS 小鼠模型中突触 RNA 的早期错误调节

Sonu Sahadevan #, Katharina M Hembach #, Elena Tantardini, Manuela Pérez-Berlanga, Marian Hruska-Plochan, Salim Megat, Julien Weber, Petra Schwarz, Luc Dupuis, Mark D Robinson, Pierre De Rossi, Magdalini Polymenidou

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

LAG3在人和小鼠的神经元中均不表达,也不调节α-突触核蛋白病。

Marc Emmenegger,Elena De Cecco,Marian Hruska-Plochan,Timo Eninger,Matthias M Schneider,Melanie Barth,Elena Tantardini,Pierre de Rossi,Mehtap Bacioglu,Rebekah G Langston,Alice Kaganovich,Nora Bengoa-Vergniory,Andrès Gonzalez-Guerra,Merve Avar,Daniel Heinzer,Regina Reimann,Lisa M Häsler,Therese W Herling,Naunehal S Matharu,Natalie Landeck,Kelvin Luk,Ronald Melki,Philipp J Kahle,Simone Hornemann,Tuomas P J Knowles,Mark R Cookson,Magdalini Polymenidou,Mathias Jucker,Adriano Aguzzi

Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions

核输入受体直接与富含精氨酸的二肽重复蛋白结合并抑制其病理性相互作用

Saskia Hutten ,Sinem Usluer ,Benjamin Bourgeois ,Francesca Simonetti ,Hana M Odeh ,Charlotte M Fare ,Mareike Czuppa ,Marian Hruska-Plochan ,Mario Hofweber ,Magdalini Polymenidou ,James Shorter ,Dieter Edbauer ,Tobias Madl ,Dorothee Dormann

Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis

记忆力下降及其在衰老和神经退行性疾病中的逆转与 miR-183/96/182 的生物合成有关

Ali Jawaid, Bisrat T Woldemichael, Eloïse A Kremer, Florent Laferriere, Niharika Gaur, Tariq Afroz, Magdalini Polymenidou, Isabelle M Mansuy

SarkoSpin: A Technique for Biochemical Isolation and Characterization of Pathological TDP-43 Aggregates

SarkoSpin:一种用于病理性 TDP-43 聚集体的生化分离和表征技术

Manuela Pérez-Berlanga, Florent Laferrière, Magdalini Polymenidou